Loss-of-function phenotype analysis in nematode worms has benefited tremendously from a well-annotated genome and the efficacy of RNAi gene-inactivation technology. In the January 16
Worms were fed on bacteria expressing double-stranded RNA for each
Worm genes with orthologues in other species were more likely to have a detectable RNAi phenotype than other genes, and genes that exist as a single copy were 2-3 times more likely to have a phenotype. Some protein domains showed association with particular types...