Redox-regulated immunity

Kwangseog Ahn of Seoul National University led a group that purified protein complexes associated with MHC class I loading and found protein disulfide isomerase (PDI) in the mix of peptides.1 PDI carries out sulfide-bond oxidation, reduction, and isomerization, assisting in the general folding of proteins with disulfide bonds. So, the link to antigen presentation was "surprising," according to Faculty of 1000 member Laurence Eisenlohr of Thomas Jefferson University in Philadelphia.


Register for free to listen to this article
Listen with Speechify
0:00
1:00
Share

Kwangseog Ahn of Seoul National University led a group that purified protein complexes associated with MHC class I loading and found protein disulfide isomerase (PDI) in the mix of peptides.1 PDI carries out sulfide-bond oxidation, reduction, and isomerization, assisting in the general folding of proteins with disulfide bonds. So, the link to antigen presentation was "surprising," according to Faculty of 1000 member Laurence Eisenlohr of Thomas Jefferson University in Philadelphia.

Eisenlohr writes: "PDI plays a major role in peptide loading of MHC class I molecules by regulating the redox state of a cysteine pair in the alpha 2 domain, previously identified as an important determinant of peptide receptivity. siRNA and mutagenesis studies reveal that PDI has both peptide-binding (chaperonin) and peptide-loading functions, and that it operates as a peptide editor, ensuring the acquisition of high-affinity peptides that are stably displayed at the cell surface.

"On top of this, the authors ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!
Already a member? Login Here
Image of a woman in a microbiology lab whose hair is caught on fire from a Bunsen burner.
April 1, 2025, Issue 1

Bunsen Burners and Bad Hair Days

Lab safety rules dictate that one must tie back long hair. Rosemarie Hansen learned the hard way when an open flame turned her locks into a lesson.

View this Issue
Characterizing Immune Memory to COVID-19 Vaccination

Characterizing Immune Memory to COVID-19 Vaccination

10X Genomics
Faster Fluid Measurements for Formulation Development

Meet Honeybun and Breeze Through Viscometry in Formulation Development

Unchained Labs
Conceptual image of biochemical laboratory sample preparation showing glassware and chemical formulas in the foreground and a scientist holding a pipette in the background.

Taking the Guesswork Out of Quality Control Standards

sartorius logo
An illustration of PFAS bubbles in front of a blue sky with clouds.

PFAS: The Forever Chemicals

sartorius logo

Products

Metrion Biosciences Logo

Metrion Biosciences launches NaV1.9 high-throughput screening assay to strengthen screening portfolio and advance research on new medicines for pain

Biotium Logo

Biotium Unveils New Assay Kit with Exceptional RNase Detection Sensitivity

Atelerix

Atelerix signs exclusive agreement with MineBio to establish distribution channel for non-cryogenic cell preservation solutions in China

Green Cooling

Thermo Scientific™ Centrifuges with GreenCool Technology

Thermo Fisher Logo