Size Matters: Princeton Separations' CentriSpin Columns

You might think there couldn't be anything new in size exclusion chromatography. Think again. Princeton Separations' CentriSpin columns are the latest addition to a variety of commercially available micro- and mini-spin columns. Three CentriSpin columns-- CentriSpin-10, CentriSpin-20, and CentriSpin-40, each with a different exclusion point--allow for a variety of applications. Princeton Separations' CentriSpin Columns These new columns contain a crosslinked dextran-polymer gel-filtration ma

Written byBob Sinclair

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Princeton Separations' CentriSpin Columns

These new columns contain a crosslinked dextran-polymer gel-filtration matrix. By a proprietary technique (presumably involving precise control of the average polymer length and the degree of crosslinking), the exclusion point of the matrix has been manipulated. This has resulted in a series of resins with different properties:

Combined with the related CentriSep columns, which have gained wide acceptance as an efficient method for removing unincorporated dye terminators from fluorescent sequencing reactions, the Princeton Separations family of mini-spin columns will address many separation needs.

Princeton Separations' Barry Yelenik says that in addition to the useful ranges of molecules that are retained or excluded by the matrix, a very important feature of the CentriSpin columns is that they can be stored and shipped dry. For a dry product, the storage and shipping environment need not be as carefully controlled as for a prehydrated column, the shelf life should ...

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