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by Emily Cox and Henry Rathvon

These observations represent yet another warning to translational medical researchers that lab mice are very imperfect predictors of results’ translation to humans. But there is a silver lining that, now, a better mouse model is available to confirm or refute promising results in traditional lab mice.

Franck Carbonero, Washington State University microbiome researcher, speaking to The Scientist about a new study that used rodents with microbiomes similar to those of wild mice to accurately predict the failure of two candidate drug treatments in humans (August 1)

It makes me wonder if they're trying to make some sort of intellectual claim rather than move the science along, or they're trying to be the first, generate hype, or somehow attract more money.

—New York University bioethicist...


1. Saturniid with 1-Down wings (2 wds.)
5. Hives, for example
8. Job for one acquainted with alpha-keratin
9. Atacama rarity
11. Study of the safety or danger of doses
14. See 3-Down
15. Hook-billed bird with a shrill cry
17. Big family of Native American languages
20. Mountains where edelweiss is wild
21. Try to eye Rigel, say
22. Bluefin or skipjack
23. Existing by nature rather than nurture


1. Shade of green
2. Band sum for Texas armadillos
3. Tiny 14-Across forms like nematodes
4. Zone straddling the equator
6. Relating to an organism’s bodily structure
7. Apis mellifera member
10. Yucca plant iconic in the Southwest (2 wds.)
12. Opacity in the lens of the eye
13. Unbeatable feature of a wandering albatross
16. Result of exposure to ultraviolet radiation
18. Typical spot for a vesper bat
19. Caterpillar’s cocoonlike home  

Jonny Hawkins

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