Special Needs: Custom Houses that Provide Specialized Oligos

LabConsumer recently took a look at custom oligo houses (J. Kling, The Scientist, 12(7) 18, March 30, 1998), and found that there's more than one kind of company: those that produce standard (commonly referred to as vanilla) oligos quickly and, for the most, part cheaply and those that specialize in oligos with an ever-increasing array of tags and modifications. Since there wasn't the time or space to do the latter group of companies justice in the previous article, this article revisits custo

Laura Defrancesco

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PE Applied Biosystems
PE offers primers and probes for PCR, TaqMan and sequence detection, GeneScan, linkage mapping and custom sequencing applications. The Custom services offered are:

800-762-4000
www.perkin-elmer.com

Cruachem
Cruachem's custom DNA and RNA synthesis service offers a comprehensive list of 104 modifications for DNA and RNA oligonucleotides, including 5 ´ -biotinylation, 5 ´ -fluorescein, triple DNP labeling, and S-oligos at up to 1 mmole scale. The company is actively involved in the research and development of second generation anti- sense oligos and labels to satisfy ever-evolving needs. Oligos are supplied desalted or at different levels of purification to meet specific project requirements: PAGE for oligos above 50 bases and for modified oligos; HPLC for >95% purity of modified oligos; and COP for 90-95% purity, suitable for most applications.

Cruachem's custom RNA service uses two different chemistries, and with targeted ion exchange, can supply RNA oligos at >95% purity. In ...

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