Stopping Hookworm

As trials get underway in Brazil, Peter Hotez and his colleagues are hoping their vaccine will put an end to a parasite's evasive immune maneuvers - and its devastating morbidity.

By Merrill Goozner

Related Articles


"The likelihood of success is not very high. This is a complex parasite that has evolved over a million years."

In 1989, Hotez moved to Yale University, where he conducted most of the early scientific work aimed at identifying a vaccine target. His early epidemiologic studies in China had revealed a wide variation in the number of worms among people who were routinely exposed to the parasite. He also knew from his early days as a graduate student that an attenuated larvae vaccine for canine hookworm had been developed in the 1960s and 1970s. Its manufacturer discontinued making it in 1975 after only a few years on the market, citing poor sales....

Interested in reading more?

Magaizne Cover

Become a Member of

Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!
Already a member?