Synthetic technologies allow scientists to venture into uncharted waters, asking unique research questions and finding previously unattainable solutions to some of life’s biggest mysteries. From gene editing to protein engineering, synthesized DNA libraries enable researchers to grasp once unreachable high-throughput screening applications and dismantle barriers between experimental ideation and execution.
In this podcast series brought to you by Twist Bioscience, The Scientist’s Creative Services Team talks to experts about their experiences implementing Twist Bioscience’s synthesized long double-stranded gene pools, Multiplexed Gene Fragments, for high-throughput screening.
Episode 1 - Engineering Gene Regulation through Creative Experimental Design
Date: August 20, 2024
In this episode, Josh Tycko, a neurobiology postdoctoral researcher in Michael Greenberg's laboratory at Harvard Medical School, talks about investigating gene regulation with synthetic DNA libraries.
Speaker:
Josh Tycko, PhD
Postdoctoral Researcher
Department of Neurobiology
Harvard Medical School
Episode 2 – Mutiplexed Gene Fragments Drive De Novo Protein Design
Date: September 3, 2024
In this episode, Jeffrey Chang, a senior graduate student in Nick Polizzi’s laboratory at Harvard University, speaks about combining computation and experimentation to develop de novo ligand-binding proteins using large gene fragment pools.
Speaker:
Jeffrey Chang
Graduate Student
Nick Polizzi Laboratory
Harvard University and Dana Farber Cancer Center
Episode 3 – Training AI Models with More Sequence Diversity to Improve Hits
Date: September 17, 2024
In this episode, Pierce Ogden, Chief Scientific Officer of Manifold Biotechnologies, discusses the power of pairing large gene fragment pools with AI-designed libraries for better therapeutic discovery and delivery.
Speaker:
Pierce Ogden, PhD
Co-founder and Chief Scientific Officer
Manifold Biotechnologies
