In an effort to restock the dwindling pipeline of new treatments, systems biology is increasingly becoming a part of drug discovery efforts.
Company
Approach
Location
Screen novel compounds with combinations of human primary cells to measure activity and understand their mechanism of action
Use models to improve quality of pre-clinical compounds and guide the design of clinical trials.? Evaluate cardiovascular safety with Visual Heart.?
Apply causal-inference models to identify biomarkers for drug toxicity, drug resistance, and cardiovascular drug mechanisms.
Rosetta Inpharmatics
(subsidiary of Merck)
Identify targets in gene networks regulating obesity, diabetes, and other phenotypic traits, using microarray techniques.
Use a human physiological model designed for understanding disease dynamics and optimizing drug and treatment schedules
Use virtual patients, recently modeling skin sensitivity for the cosmetics industry.
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