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Illustration of green fluorescent bacterial cells.
Cocaine Use Creates Feedback Loop with Gut Bacteria: Mouse Study
A jolt of norepinephrine in the mouse gut facilitates colonization by certain microbes, which in turn deplete glycine, enhancing cocaine-induced behaviors.
Cocaine Use Creates Feedback Loop with Gut Bacteria: Mouse Study
Cocaine Use Creates Feedback Loop with Gut Bacteria: Mouse Study

A jolt of norepinephrine in the mouse gut facilitates colonization by certain microbes, which in turn deplete glycine, enhancing cocaine-induced behaviors.

A jolt of norepinephrine in the mouse gut facilitates colonization by certain microbes, which in turn deplete glycine, enhancing cocaine-induced behaviors.

cocaine

Rodents Offer New Insights Into the Diversity of Addiction
Aparna Nathan, PhD | Dec 1, 2023 | 4 min read
Molecular studies may point to underlying genetics and therapeutic targets.
pile of powdered cocaine and 3 lines on black surface
Gene-Edited Skin Patch Prevents Cocaine Overdose in Mice
Shawna Williams | Sep 17, 2018 | 4 min read
With a built-in supply of a powerful cocaine-chomping enzyme, the transplant might also curb addiction.
Cocaine Induces Neuronal Autophagy
Jef Akst | Jan 19, 2016 | 1 min read
A new study supports the idea that cocaine triggers brain cells to eat themselves and suggests a possible antidote.
Toward a Cocaine Vaccine
Jef Akst | Jan 22, 2015 | 1 min read
A modified bacterial protein elicits a robust immune response against a cocaine-linked molecule in mice.
Suppressing Drug-Seeking Behaviors
Abby Olena, PhD | Nov 24, 2013 | 4 min read
Augmenting the action of a glutamate receptor in the brains of addicted rats helps prevent them from seeking cocaine during withdrawal, a study shows.
The Epigenetics of Drug Abuse
Jef Akst | Nov 11, 2013 | 1 min read
At the Society for Neuroscience conference, researchers present results linking the epigenome to heroin and cocaine addiction.
Week in Review: August 12–16
Tracy Vence | Aug 16, 2013 | 3 min read
Engineered immune cells attack tumors; a mouth microbe that can cause cancer; HIV may heighten cocaine’s high; craving high-fat foods
Inca Children Got High Before Death
Chris Palmer | Jul 29, 2013 | 2 min read
Evidence from mummified remains of three children discovered atop an Argentinian volcano suggests they were drunk and stoned for a year leading up to their ritual sacrifice.
Inherited Resistance to Cocaine
Ed Yong | Dec 17, 2012 | 3 min read
Cocaine-using rat fathers pass epigenetic changes on to their sons that make them resistant to coke addiction.
An Antidote for Cocaine Overdose?
Cristina Luiggi | Apr 19, 2012 | 1 min read
A novel antibody with a powerful affinity for cocaine shows promise in reversing the deadly effects of an overdose.
Reversing Cocaine’s Effects with Light
Ruth Williams | Dec 7, 2011 | 3 min read
Researchers use optogenetics to reverse drug-induced brain and behavioral changes.
Cigarette Smoking Leads to Coke?
Jef Akst | Nov 4, 2011 | 2 min read
Nicotine may alter the brain’s response to cocaine, supporting the idea that the legal drug may serve as a "gateway" to the use of illegal substances.
Shooting Down Addiction
Thomas Kosten | Jun 1, 2011 | 10+ min read
A new breed of vaccines aims to wean users off cocaine.
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