HIV pathogenesis

Mice transplanted with human hematopoietic stem cells that have an HIV receptor gene, CCR5, disrupted by gene editing allows the animals to ward off HIV infection. 

The virus that causes AIDS can replicate and mutate in the brain as early as four months after initial infection, according to a new study.

During HIV infection, CD4 T cells in lymphoid tissues initiate a highly inflammatory form of cell death that helps cripple the immune system.
 

Chilly mice develop more tumors; gut bacteria aid cancer treatment; two Y chromosome genes sufficient for assisted reproduction; HIV’s “invisibility cloak”

Monkeys infected with simian immunodeficiency virus have a higher diversity of gut viruses, pointing to a possible role of the virome in SIV pathogenesis.