Spleen-to-Liver Signals Control Systemic Inflammation
Spleen-to-Liver Signals Control Systemic Inflammation
In rats, the spleen directs a cytokine surge that drives system-wide inflammation, but it is not, as once believed, the main producer of the chemical messenger.
Spleen-to-Liver Signals Control Systemic Inflammation
Spleen-to-Liver Signals Control Systemic Inflammation

In rats, the spleen directs a cytokine surge that drives system-wide inflammation, but it is not, as once believed, the main producer of the chemical messenger.

In rats, the spleen directs a cytokine surge that drives system-wide inflammation, but it is not, as once believed, the main producer of the chemical messenger.

liver
Organoids Repair Bile Ducts
Organoids Repair Bile Ducts
Abby Olena | Feb 18, 2021
Researchers determined that when introduced into damaged mouse or donated human livers, these lab-grown tissues could integrate into bile ducts and function normally.
Stress-Induced Chromosome Changes Protect Flies’ Aging Brains
Stress-Induced Chromosome Changes Protect Flies’ Aging Brains
Lisa Winter | Dec 1, 2020
Brain cells in older Drosophila tend to have more than two complete sets of chromosomes, and that polyploidy most likely has a protective function, a study shows.
Image of the Day: Red-Feathered Finches
Image of the Day: Red-Feathered Finches
Emily Makowski | Sep 30, 2019
Scientists uncover a potential reason why redder house finches have better health.
Gut Microbe Linked to Nonalcoholic Fatty Liver Disease
Gut Microbe Linked to Nonalcoholic Fatty Liver Disease
Abby Olena | Sep 19, 2019
Researchers find strains of the bacterium Klebsiella pneumoniae that produce high levels of alcohol in 60 percent of patients with the condition.
Exosomes from Blood Carry RNA Signatures of Liver Cancer
Exosomes from Blood Carry RNA Signatures of Liver Cancer
Emma Yasinski | Apr 2, 2019
A small study finds that the tiny extracellular vesicles from patients with hepatocellular carcinoma have RNA content distinct from patients with cirrhosis only.
Just the Sight of Food Gets the Liver Ready for Action
Just the Sight of Food Gets the Liver Ready for Action
Abby Olena | Nov 15, 2018
In mice, seeing and smelling food causes immediate cellular changes that ready the liver to convert incoming amino acids to proteins.
CRISPR Editing Heads Off Disease in Mouse Livers
CRISPR Editing Heads Off Disease in Mouse Livers
Shawna Williams | Oct 9, 2018
Separate proof-of-concept studies report success against two inherited diseases.
Limited Meal Times Prevent Obesity in Mice Prone to Gaining Weight
Limited Meal Times Prevent Obesity in Mice Prone to Gaining Weight
Abby Olena | Aug 30, 2018
Even in mice with a busted circadian clock and an unhealthy diet, carefully timed feeding overcomes the rodents’ predispositions for metabolic diseases.
Reprogrammed Cells Treat Diabetes in Mice
Reprogrammed Cells Treat Diabetes in Mice
Abby Olena | May 2, 2018
Researchers used a trio of transcription factors to transform pancreatic duct cells in vivo into β-like cells that secrete insulin and improve diabetes symptoms.
Man Receives First In Vivo Gene-Editing Therapy
Man Receives First In Vivo Gene-Editing Therapy
Kerry Grens | Nov 14, 2017
The 44-year-old patient has Hunter syndrome, which doctors hope to treat using zinc finger nucleases.
Macrophages Are the Ultimate Multitaskers
Macrophages Are the Ultimate Multitaskers
Claire Asher | Oct 1, 2017
From guiding branching neurons in the developing brain to maintaining a healthy heartbeat, there seems to be no job that the immune cells can’t tackle.
Infographic: Macrophages Around the Body
Infographic: Macrophages Around the Body
Claire Asher | Sep 30, 2017
In addition to circulating in the blood as immune sentinels, macrophages play specialized roles in different organs around the body.
Image of the Day: Mitochondria, Live and in Color
Image of the Day: Mitochondria, Live and in Color
The Scientist Staff | Sep 27, 2017
Mitochondria age differently depending upon whether they’re located in the liver, heart, or kidney, scientists find in flies and mice.
Engineered Human Liver Tissue Grows in Mice
Engineered Human Liver Tissue Grows in Mice
Anna Azvolinsky | Jul 19, 2017
Tissue “seeds” made up of three cell types and patterned onto a scaffold develop into complex structures with some organ function, researchers show.
Image of the Day: Liver Buds
Image of the Day: Liver Buds
The Scientist Staff | Jun 16, 2017
Using human induced pluripotent stem cells, scientists grew liver organoids and studied gene expression patterns in individual cells to learn more about how these tissues develop. 
Infographic: A Body Without Food
Infographic: A Body Without Food
Bob Grant | May 31, 2017
Mounting evidence suggests that intermittent fasting causes significant changes to various organs and tissue types.
First In Vivo Human Genome Editing to Be Tested in New Clinical Trial
First In Vivo Human Genome Editing to Be Tested in New Clinical Trial
Abby Olena | May 18, 2017
Sangamo Therapeutics will use zinc finger nucleases to introduce the gene for a missing clotting factor into the livers of men with hemophilia B.
Mouse Livers Grow and Shrink Daily
Mouse Livers Grow and Shrink Daily
Abby Olena | May 4, 2017
Feeding-fasting rhythms and light-dark cycles direct regular changes in organ and cell size, as well as ribosome number and protein levels.
Newly Discovered Emergency Responders to Liver Damage
Newly Discovered Emergency Responders to Liver Damage
Ashley P. Taylor | Aug 1, 2016
Immune cells called macrophages from the peritoneal cavity of mice migrate to injured livers and aid in repair.