Vitamin D Deficiency Drives Opioid Addiction in Mice
Vitamin D Deficiency Drives Opioid Addiction in Mice
Mice with low vitamin D had exaggerated craving for opioids and felt the drugs’ effects more strongly—results supported in part by human medical records—suggesting that supplements should be explored as treatments for opioid use disorders.
Vitamin D Deficiency Drives Opioid Addiction in Mice
Vitamin D Deficiency Drives Opioid Addiction in Mice

Mice with low vitamin D had exaggerated craving for opioids and felt the drugs’ effects more strongly—results supported in part by human medical records—suggesting that supplements should be explored as treatments for opioid use disorders.

Mice with low vitamin D had exaggerated craving for opioids and felt the drugs’ effects more strongly—results supported in part by human medical records—suggesting that supplements should be explored as treatments for opioid use disorders.

opioids
Opinion: The Overlooked Power of Inhibitory Neurons
Opinion: The Overlooked Power of Inhibitory Neurons
Lauren Aguirre | Jun 1, 2021
Understanding how the brain coordinates electrical activity could be key to developing more-effective treatments for a variety of brain disorders.
Opinion: We Still Lack Evidence that Cannabis Treats Cancer Pain
Opinion: We Still Lack Evidence that Cannabis Treats Cancer Pain
Jason Boland and Elaine Boland | Apr 1, 2020
Only an equal mixture of THC and CBD has been adequately tested, and it failed to alleviate pain in cancer patients.
Book Excerpt from <em>Drugs Without the Hot Air</em>
Book Excerpt from Drugs Without the Hot Air
David Nutt | Feb 24, 2020
In Chapter 14, author David Nutt describes the opioid crisis currently besetting the US.
Tufts to Remove Sackler Name from Medical Campus
Tufts to Remove Sackler Name from Medical Campus
Emily Makowski | Dec 9, 2019
The school will not return donations from the family that made its riches on opioids, but the university will start a $3 million endowment for addiction prevention and treatment.
Is Kratom Safe During Pregnancy? Researchers Start to Investigate
Is Kratom Safe During Pregnancy? Researchers Start to Investigate
Katarina Zimmer | Jul 26, 2019
Recent reports of babies born with opioid withdrawal symptoms after their mothers used kratom during pregnancy have generated much concern about the medicinal herb.
Opioid Settlement Money to Fund Addiction Research Center
Opioid Settlement Money to Fund Addiction Research Center
Ashley Yeager | Apr 3, 2019
Oklahoma dropped its lawsuit against OxyContin-maker Purdue Pharma in exchange for a National Center for Addiction Studies and Treatment in Tulsa.
Synthetic Botox Treats Chronic Pain in Mice
Synthetic Botox Treats Chronic Pain in Mice
Abby Olena | Jul 18, 2018
Researchers silence pain neurons in the mouse spinal cord with injections of botulinum toxins modified to bind to the neurons’ receptors.
FDA Approves Drug to Ease Symptoms of Opioid Withdrawal
FDA Approves Drug to Ease Symptoms of Opioid Withdrawal
Catherine Offord | May 17, 2018
Lucemyra is the first non-opioid drug to be approved in the U.S. specifically for this purpose.
NIH Won’t Use Industry Money for Opioid Research Initiative
NIH Won’t Use Industry Money for Opioid Research Initiative
Shawna Williams | Apr 19, 2018
The announcement comes after an agency working group recommends against an industry partnership on ethical grounds.
CDC, FDA Warn Against Kratom Use
CDC, FDA Warn Against Kratom Use
Jim Daley | Feb 25, 2018
The herbal supplement, deemed an opioid by the FDA, was recently linked to a Salmonella outbreak in 20 states. 
FDA Declares Kratom an Opioid. We’re Here to Explain What It Does.
FDA Declares Kratom an Opioid. We’re Here to Explain What It Does.
Jim Daley | Feb 7, 2018
The Scientist speaks with a clinical toxicologist to discuss how the supplement acts in the brain and what the agency's declaration means for research.
Sex Differences in Opioid Analgesia: A Complicated Picture
Sex Differences in Opioid Analgesia: A Complicated Picture
Catherine Offord | Jan 1, 2018
Researchers are beginning to tease apart the mechanisms underlying differences in how males and females respond to powerful painkillers.
Painful Realities
Painful Realities
The Scientist Staff | Dec 31, 2017
Dave Thomas, a researcher at the National Institute on Drug Abuse, talks about the harsh truths and frustrating complexity of pain and analgesia.
CDC Offers Advice to Limit Opioid Scripts
CDC Offers Advice to Limit Opioid Scripts
Kerry Grens | Mar 17, 2016
Aimed at primary care providers, the recommendations encourage non-narcotic alternatives or short-term opioid prescriptions and patient monitoring.
Heady Stuff
Heady Stuff
Kate Yandell | Nov 1, 2015
New research on how fat influences brain neuronal activity
Yeast-Based Opioid Production Completed
Yeast-Based Opioid Production Completed
Amanda B. Keener | Aug 13, 2015
Researchers fully engineer a biochemical pathway that turns a sugar into an opioid in Saccharomyces cerevisiae.
Morphine’s Missing Link Found
Morphine’s Missing Link Found
Amanda B. Keener | Jun 29, 2015
Researchers identified the last poppy gene product needed to produce morphine in yeast.
Yeast–Made Opioid Progresses
Yeast–Made Opioid Progresses
Tracy Vence | May 19, 2015
Scientists are one step closer to coaxing engineered yeast to produce morphine from a simple sugar.
Toward Yeast–Based Opioid Production
Toward Yeast–Based Opioid Production
Tracy Vence | Aug 24, 2014
Synthetic biologists introduce bacterial and poppy plant genes into yeast to manufacture morphine.