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Closeup of a pair of hands in blue gloves holding a white mouse and injecting it with an amber colored liquid.
Opioids Recruit the Immune System to Cause Withdrawal Symptoms
A study finds that T cells induced by heroin cross the blood-brain barrier to wreak havoc on the brain, hinting at new ways to prevent withdrawal.
Opioids Recruit the Immune System to Cause Withdrawal Symptoms
Opioids Recruit the Immune System to Cause Withdrawal Symptoms

A study finds that T cells induced by heroin cross the blood-brain barrier to wreak havoc on the brain, hinting at new ways to prevent withdrawal.

A study finds that T cells induced by heroin cross the blood-brain barrier to wreak havoc on the brain, hinting at new ways to prevent withdrawal.

opioids
Vaccine illustration 
Infographic: Inducing Active Immunity Against Opioid Overdose
Tori Rodriguez | Jun 13, 2022 | 3 min read
How scientists aim to induce an immune response against addictive drugs
Illustration of a syringe with a person falling out of a bottle of pills
Opioid Vaccines as a Tool to Stem Overdose Deaths
Tori Rodriguez | Jun 13, 2022 | 10+ min read
Researchers are turning to the immune system for help in treating addiction and preventing overdose.
US Capitol with Senate building in the foreground
Robert Califf Confirmed to Lead FDA
Shawna Williams | Feb 15, 2022 | 1 min read
A narrow Senate vote ends a 13-month period during which the agency has lacked a permanent commissioner.
Two fingers grasp a vitamin D capsule
Vitamin D Deficiency Drives Opioid Addiction in Mice
Amanda Heidt | Jun 16, 2021 | 5 min read
Mice with low vitamin D had exaggerated craving for opioids and felt the drugs’ effects more strongly—results supported in part by human medical records—suggesting that supplements should be explored as treatments for opioid use disorders.
illustration of a neuron connected to other neurons
Opinion: The Overlooked Power of Inhibitory Neurons
Lauren Aguirre | Jun 1, 2021 | 3 min read
Understanding how the brain coordinates electrical activity could be key to developing more-effective treatments for a variety of brain disorders.
Opinion: We Still Lack Evidence that Cannabis Treats Cancer Pain
Jason Boland and Elaine Boland | Apr 1, 2020 | 3 min read
Only an equal mixture of THC and CBD has been adequately tested, and it failed to alleviate pain in cancer patients.
Book Excerpt from Drugs Without the Hot Air
David Nutt | Feb 24, 2020 | 4 min read
In Chapter 14, author David Nutt describes the opioid crisis currently besetting the US.
Tufts to Remove Sackler Name from Medical Campus
Emily Makowski | Dec 9, 2019 | 2 min read
The school will not return donations from the family that made its riches on opioids, but the university will start a $3 million endowment for addiction prevention and treatment.
kratom opioid pregnancy
Is Kratom Safe During Pregnancy? Researchers Start to Investigate
Katarina Zimmer | Jul 26, 2019 | 8 min read
Recent reports of babies born with opioid withdrawal symptoms after their mothers used kratom during pregnancy have generated much concern about the medicinal herb.
Opioid Settlement Money to Fund Addiction Research Center
Ashley Yeager | Apr 3, 2019 | 1 min read
Oklahoma dropped its lawsuit against OxyContin-maker Purdue Pharma in exchange for a National Center for Addiction Studies and Treatment in Tulsa.
Synthetic Botox Treats Chronic Pain in Mice
Abby Olena, PhD | Jul 18, 2018 | 3 min read
Researchers silence pain neurons in the mouse spinal cord with injections of botulinum toxins modified to bind to the neurons’ receptors.
FDA Approves Drug to Ease Symptoms of Opioid Withdrawal
Catherine Offord | May 17, 2018 | 1 min read
Lucemyra is the first non-opioid drug to be approved in the U.S. specifically for this purpose.
NIH Won’t Use Industry Money for Opioid Research Initiative
Shawna Williams | Apr 19, 2018 | 1 min read
The announcement comes after an agency working group recommends against an industry partnership on ethical grounds.
CDC, FDA Warn Against Kratom Use
Jim Daley | Feb 25, 2018 | 2 min read
The herbal supplement, deemed an opioid by the FDA, was recently linked to a Salmonella outbreak in 20 states. 
FDA Declares Kratom an Opioid. We’re Here to Explain What It Does.
Jim Daley | Feb 7, 2018 | 3 min read
The Scientist speaks with a clinical toxicologist to discuss how the supplement acts in the brain and what the agency's declaration means for research.
Sex Differences in Opioid Analgesia: A Complicated Picture
Catherine Offord | Jan 1, 2018 | 5 min read
Researchers are beginning to tease apart the mechanisms underlying differences in how males and females respond to powerful painkillers.
Painful Realities
The Scientist Staff | Dec 31, 2017 | 1 min read
Dave Thomas, a researcher at the National Institute on Drug Abuse, talks about the harsh truths and frustrating complexity of pain and analgesia.
CDC Offers Advice to Limit Opioid Scripts
Kerry Grens | Mar 17, 2016 | 1 min read
Aimed at primary care providers, the recommendations encourage non-narcotic alternatives or short-term opioid prescriptions and patient monitoring.
Heady Stuff
Kate Yandell | Nov 1, 2015 | 5 min read
New research on how fat influences brain neuronal activity
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