Giannina Descalzi
Giannina Descalzi Studies the Factors Underlying Chronic Pain
The University of Guelph neuroscientist is scoping out the brain regions and genes that change as a consequence of pain that lasts for months or even years.
ABOVE: University of Guelph
Giannina Descalzi Studies the Factors Underlying Chronic Pain
Giannina Descalzi Studies the Factors Underlying Chronic Pain

The University of Guelph neuroscientist is scoping out the brain regions and genes that change as a consequence of pain that lasts for months or even years.

The University of Guelph neuroscientist is scoping out the brain regions and genes that change as a consequence of pain that lasts for months or even years.

ABOVE: University of Guelph

pain

Senior woman wearing a grey pullover sitting on a bed and holding her back.
Early Inflammation Protects Against Chronic Pain, Study Finds
Alejandra Manjarrez | May 12, 2022
Human data and experiments in mice challenge the common use of anti-inflammatory drugs to treat pain.
Rounded red and green fluorescent cells are visible on a light and dark gray background
Neurons Firing Together Generate Spontaneous Pain
Abby Olena | Nov 10, 2021
Abnormal sympathetic neuron growth leads to simultaneous activation of clusters of sensory neurons, causing the difficult-to-treat sensation.
Mapping Neuronal Gene Expression to Understand Pain
The Scientist Creative Services Team in collaboration with Advanced Cell Diagnostics | Jul 15, 2021
Ted Price, Diana Tavares-Ferreira, and Stephanie Shiers discuss how mapping gene expression at the neuronal level provides insight into pain mechanisms and anti-pain drug development.
sketch of two men smiling
Mechanisms of Chili’s Heat, Menthol’s Cool Garner Nobel
Chloe Tenn | Oct 4, 2021
David Julius and Ardem Patapoutian won this year’s Nobel Prize in Physiology or Medicine for their research on the ion channels involved in perceiving heat, cold, pain, and touch.
morphine drip
Morphine Tolerance Pathway Identified in Mice
David Adam | Sep 20, 2021
Prolonged exposure to morphine triggers cells in the spine to release signaling molecules that increase pain sensitivity and dull the relief of the drug. Blocking this activity could improve pain management.
The MSC: Regeneration Orchestrator
The Scientist Staff | Nov 16, 2020
Scientists uncover the promise of mesenchymal stem cells (MSCs), also known as medicinal signaling cells, to modulate the immune system and regenerate tissue.
two doctors looking at a medical monitor showing electrodes being inserted near a person's spinal cord
Low Frequency Electric Stimulation Can Treat Back Pain: Study
Emma Yasinski | Sep 2, 2021
Patients in a small trial said their chronic pain improved an average of 90 percent over the course of 15 days, but returned shortly after the electrical stimulation sessions ended.
illustration of a blue neuron lit with red
Neuron-Released Protein Can Set Off Inflammation: Study
Marcus A. Banks | Aug 19, 2021
Research in mice suggests that moderating nerve activity with drugs or electrical pulses could modify tissue immune responses, curtailing the chronic pain often associated with inflammatory conditions.
Pain Researcher Quits Academia, Takes Lab Home with Him
Jef Akst | May 1, 2021
After resigning from the University of New England last year, Geoffrey Bove continues to study the effects of massage on rats in a facility he set up in his house.
neuroscience, mice, fear, pain, empathy, social transmission, emotion contagion, optogenetics, analgesia, Stanford University
Mice Share Each Other’s Pain and Fear
Amanda Heidt | Jan 14, 2021
The animals adopt the emotional state of their cagemates, and the parts of the brain engaged during the process are different for pain and fear, according to a new study.
Losing Touch: Another Drawback of the COVID-19 Pandemic
Ashley Yeager | May 19, 2020
Affectionate touches tap into the nervous system’s rest and digest mode, reducing the release of stress hormones, bolstering the immune system, and stimulating brainwaves linked with relaxation.
Facial Expressions Decoded in Mice
Ruth Williams | Apr 2, 2020
A combination of videography, machine learning, and brain imaging has identified facial expressions and neural activity patterns in mice that are associated with their emotions.
Opinion: We Still Lack Evidence that Cannabis Treats Cancer Pain
Jason Boland and Elaine Boland | Apr 1, 2020
Only an equal mixture of THC and CBD has been adequately tested, and it failed to alleviate pain in cancer patients.
Image of the Day: Lumbar Support
Amy Schleunes | Mar 24, 2020
An experimental tissue engineering treatment that addresses damage at both the inner core and outer ring of sheep intervertebral discs improves spinal structure and function.
mitochondrial transfer mitochondria inflammation pain
Macrophages in Mice Shuttle Mitochondria to Neurons in Need
Katarina Zimmer | Mar 5, 2020
The findings could represent a novel mechanism for relieving inflammatory pain.
Image of the Day: Marijuana for Endometriosis?
Amy Schleunes | Jan 31, 2020
THC, the psychoactive ingredient of cannabis, improved symptoms associated with the inflammatory disease in a mouse model.
Fish Biologist Victoria Braithwaite Dies
Catherine Offord | Oct 30, 2019
The Penn State University scientist was known for her work on fish’s perception of pain.
How Evolution Made the Highveld Mole Rat Impervious to Ant Stings
Shawna Williams | Sep 1, 2019
Researchers identify changes to a pain receptor and to an ion channel that appear to enable the rodents to colonize otherwise inhospitable burrows.
schwann cells
Special Schwann Cells in Mice Play Unsung Role in Pain
Nicoletta Lanese | Aug 16, 2019
The glia seem to make up part of a newly described sensory organ, the discoverers suggest.