Blind Mole Rats Use Junk DNA to Combat Cancer
Blind Mole Rats Use Junk DNA to Combat Cancer
Activation of retrotransposons in the animals’ cancerous cells sets off an innate immune response that triggers cell death.
Blind Mole Rats Use Junk DNA to Combat Cancer
Blind Mole Rats Use Junk DNA to Combat Cancer

Activation of retrotransposons in the animals’ cancerous cells sets off an innate immune response that triggers cell death.

Activation of retrotransposons in the animals’ cancerous cells sets off an innate immune response that triggers cell death.

transposons
DNA in Cell Cytoplasm Implicated in Age-Related Blindness
DNA in Cell Cytoplasm Implicated in Age-Related Blindness
Katarina Zimmer | Sep 29, 2021
A new study suggests that DNA synthesized in the cell cytoplasm drives retinal cell death in an advanced form of age-related macular degeneration, a leading cause of blindness.
<em>Alu </em>Leap May Explain Why Apes Don&rsquo;t Have Tails
Alu Leap May Explain Why Apes Don’t Have Tails
Annie Melchor | Sep 23, 2021
A transposable element that jumped into the TBXT gene, which is linked to tail morphology, appears to be to blame for our missing appendage.
Male Flies&rsquo; Y Chromosome May Contribute to Earlier Deaths
Male Flies’ Y Chromosome May Contribute to Earlier Deaths
Jef Akst | Jul 13, 2020
As male Drosophila grow old, selfish genetic elements that are abundant on the Y chromosome become more active, which appears to reduce longevity.
Transposons Identified as Likely Cause of Undiagnosed Diseases
Transposons Identified as Likely Cause of Undiagnosed Diseases
Jef Akst | Jan 13, 2020
A tool for identifying jumping gene insertions in DNA sequencing data turns up possible explanations for four patients’ rare developmental disorders.
Taming the Transposon Hordes
Taming the Transposon Hordes
Ruth Williams | Jan 1, 2019
Researchers repurpose the CRISPR machinery to turn whole classes of transposable elements on or off.
Jumping Genes Inactivated with CRISPR in Pigs
Jumping Genes Inactivated with CRISPR in Pigs
Shawna Williams | Aug 10, 2017
The study could pave the way for transplanting porcine organs to humans without the risk of reigniting endogenous retroviruses.
A Walk on the Wild Side
A Walk on the Wild Side
Mary Beth Aberlin | Feb 1, 2017
Plants have so much to teach us.
RNA Pathway Helps Keep Flies Alive
RNA Pathway Helps Keep Flies Alive
Ben Andrew Henry | Dec 21, 2016
An anti-transposon pathway previously thought to function only in reproductive tissue also helps reduce harmful mutations in body cells of fruit flies.
Gene Behind Black Peppered Moth’s Color Change Identified
Gene Behind Black Peppered Moth’s Color Change Identified
Tanya Lewis | Jun 6, 2016
A transposon underlies this classic story of evolutionary adaptation.
Tethering Transposons
Tethering Transposons
Ruth Williams | Oct 15, 2015
Panoramix, a newly identified transcription repressor, takes the bounce out of jumping genes.
Wrangling Retrotransposons
Wrangling Retrotransposons
Andrei Seluanov, Michael Van Meter, Vera Gorbunova | Mar 1, 2015
These mobile genetic elements can wreak havoc on the genome. Researchers are now trying to understand how such activity contributes to the aging process.
How Transposons Shaped Pregnancy
How Transposons Shaped Pregnancy
Kate Yandell | Jan 29, 2015
A mass migration of mobile regulatory elements increased the expression of thousands of genes in the uterus during the evolution of pregnancy.
A Movable Defense
A Movable Defense
Eugene V. Koonin and Mart Krupovic | Jan 1, 2015
In the evolutionary arms race between pathogens and hosts, genetic elements known as transposons are regularly recruited as assault weapons for cellular defense.
Contributors
Contributors
Molly Sharlach | Jan 1, 2015
Meet some of the people featured in the January 2015 issue of The Scientist.
Performance Art
Performance Art
Mary Beth Aberlin | Jan 1, 2015
Regulation of genome expression orchestrates the behavior of insect castes and the human response to social stress.
A Long Line of LINEs
A Long Line of LINEs
Kate Yandell | Sep 1, 2014
Different mechanisms repress mobile DNA elements in human embryonic stem cells depending on the elements’ evolutionary ages.
Newly ID’d Transposons Involve Cas
Newly ID’d Transposons Involve Cas
Kerry Grens | May 27, 2014
Researchers uncover a group of mobile genetic elements in bacteria and archaea encoding a Cas enzyme.
Schizophrenia’s Jumping Genetics
Schizophrenia’s Jumping Genetics
Jef Akst | Jan 6, 2014
Researchers find evidence that transposable elements, also known as jumping genes, may contribute to the development of the psychiatric disorder.
Shushing RNA
Shushing RNA
Edyta Zielinska | Aug 1, 2013
The cell detains potentially harmful RNA messages in the spliceosome long enough to create interfering RNAs against the aberrant messages.