Pioneering Research in E3 Ubiquitin Ligase Biology and Applications to Drug Discovery
The Scientist Creative Services Team in collaboration with Bio-Techne | Sep 15, 2021
Jennifer Johnston discusses how a better understanding of ubiquitin-proteasome system elements can potentially aid neurodegenerative disease therapeutics.
Infographic: Proteasome Basics
John Hines and Craig M. Crews | Apr 30, 2017
The structure and function of the cell's protein-degrading machine
Biochemistry Pioneer Dies
Tracy Vence | Jun 2, 2015
Irwin “Ernie” Rose, who shared the 2004 Nobel Prize in Chemistry for his work on ubiquitin-mediated protein degradation, has passed away at age 88.
Cellular Garbage Disposal Illuminated
Bob Grant | Apr 13, 2015
A Harvard team shows how cells label and recognize proteins for degradation.
Neil Bence: Manipulating Degradation
Kerry Grens | Dec 1, 2012
Senior Scientist, Millennium Pharmaceuticals: The Takeda Oncology Company Age: 39
Ubiquitin Chains in Action
Keith D. Wilkinson and David Fushman | Jul 1, 2012
Present in every tissue of the body, ubiquitin appears to be involved in a dizzying array of functions, from cell cycle and division to organelle and ribosome biogenesis, as well as the response to viral infection. The protein plays at least two role
Daniel Durocher: Change is Good
Kerry Grens | Jul 1, 2012
Senior Investigator, Samuel Lunenfeld Research Institute, Toronto, Ontario, Canada. Age 40
On the Chain Gang
Keith D. Wilkinson and David Fushman | Jul 1, 2012
More than simply helping haul out a cell’s garbage, ubiquitin, with its panoply of chain lengths and shapes, marks and regulates many unrelated cellular processes.
Ubiquitin basics
Keith D. Wilkinson and David Fushman | Jul 1, 2012
Despite its discovery as a protein that seems to show up everywhere, at least in eukaryotic cells, researchers are only beginning to scratch the surface of all of the cellular functions involving ubiquitin. 
Forced Feeding
Edyta Zielinska | Feb 1, 2012
Editor's choice in drug development
Come Inside
Richard P. Grant | Mar 1, 2011
Editor's choice in immunology
The Genes of Parkinson’s Disease
Bobby Thomas and M. Flint Beal | Feb 1, 2011
The minority of Parkinson’s cases now known to have genetic origins are shedding light on the cellular mechanisms of all the rest, bringing researchers closer to a cause—and perhaps a cure.
hepatitis c lasker award
Six Scientists Receive Lasker Awards
Eugene Russo | Oct 15, 2000
Ubiquitin-related research has made the transition from the basic to clinical arena in the past decade, and the field is now central to understanding diseases ranging from cancer to neurodegenerative disorders.