Taxol Synthesis

I read with interest the article in the Hot Papers column on K.C. Nicolaou's paper titled "Total synthesis of taxol" (The Scientist, May 29, 1995, page 14). The account is very helpful in bringing readers' attention to one of the most impressive achievements of chemists in recent years. It is, however, misleading in two aspects. First, the article failed to point out the actual research team that accomplished the first total synthesis of taxol. Second, it didn't mention the fact that two resea

Written byTianhan Xue
| 2 min read

Register for free to listen to this article
Listen with Speechify
0:00
2:00
Share

The account is very helpful in bringing readers' attention to one of the most impressive achievements of chemists in recent years. It is, however, misleading in two aspects. First, the article failed to point out the actual research team that accomplished the first total synthesis of taxol. Second, it didn't mention the fact that two research groups, working independently of each other, have achieved the first two syntheses of taxol at almost the same time. The legend to the picture reads: "K.C. Nicolaou's research group reported the first completely chemical synthesis of taxol." This gives readers an incorrect impression that Nicolaou's team was in first place in the heated race for the synthesis of taxol.

According to Chemical & Engineering News (Feb. 21, 1994, page 32), the official mouthpiece of the chemistry community, it is chemistry professor R.A. Holton and his coworkers at Florida State University, Tallahassee, who first achieved ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!
Already a member? Login Here

Related Topics

Meet the Author

Published In

Share
Image of a woman with her hands across her stomach. She has a look of discomfort on her face. There is a blown up image of her stomach next to her and it has colorful butterflies and gut bacteria all swarming within the gut.
November 2025, Issue 1

Why Do We Feel Butterflies in the Stomach?

These fluttering sensations are the brain’s reaction to certain emotions, which can be amplified or soothed by the gut’s own “bugs".

View this Issue
Olga Anczukow and Ryan Englander discuss how transcriptome splicing affects immune system function in lung cancer.

Long-Read RNA Sequencing Reveals a Regulatory Role for Splicing in Immunotherapy Responses

Pacific Biosciences logo
Research Roundtable: The Evolving World of Spatial Biology

Research Roundtable: The Evolving World of Spatial Biology

Conceptual cartoon image of gene editing technology

Exploring the State of the Art in Gene Editing Techniques

Bio-Rad
Conceptual image of a doctor holding a brain puzzle, representing Alzheimer's disease diagnosis.

Simplifying Early Alzheimer’s Disease Diagnosis with Blood Testing

fujirebio logo

Products

Eppendorf Logo

Research on rewiring neural circuit in fruit flies wins 2025 Eppendorf & Science Prize

Evident Logo

EVIDENT's New FLUOVIEW FV5000 Redefines the Boundaries of Confocal and Multiphoton Imaging

Evident Logo

EVIDENT Launches Sixth Annual Image of the Year Contest

10x Genomics Logo

10x Genomics Launches the Next Generation of Chromium Flex to Empower Scientists to Massively Scale Single Cell Research