That's the Spot!

Autogen separates signal from background on microarray images. Microarray technology is revolutionizing drug discovery, genetic diagnostics, and genomic research. However, processing and analyzing images can be problematic. Semiautomated processing tools such as BioDiscovery's ImaGene™ now enable scientists to process images more efficiently and quickly. Given the array boundaries, this technology locates each spot, and graphic user interface tools facilitate manual correction of misidenti

Written byAileen Constans
| 2 min read

Register for free to listen to this article
Listen with Speechify
0:00
2:00
Share


Autogen separates signal from background on microarray images.
Microarray technology is revolutionizing drug discovery, genetic diagnostics, and genomic research. However, processing and analyzing images can be problematic. Semiautomated processing tools such as BioDiscovery's ImaGene now enable scientists to process images more efficiently and quickly. Given the array boundaries, this technology locates each spot, and graphic user interface tools facilitate manual correction of misidentified spots.

Although semiautomated processing software provides clear advantages over previous microarray image analysis methods, its accuracy depends on the user's knowledge and experience. A fully automated system would provide consistency and minimize the possibility of human error. To this end, BioDiscovery has recently introduced the AutoGene Microarray Image Analysis System, a fully automated system that searches an image for DNA hybridization spots without any human assistance. AutoGene, which works with both membranes and slides, detects and separates spot signals from contamination and background. The operator just inputs ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!
Already a member? Login Here

Meet the Author

Published In

Share
Image of a woman with her hands across her stomach. She has a look of discomfort on her face. There is a blown up image of her stomach next to her and it has colorful butterflies and gut bacteria all swarming within the gut.
November 2025, Issue 1

Why Do We Feel Butterflies in the Stomach?

These fluttering sensations are the brain’s reaction to certain emotions, which can be amplified or soothed by the gut’s own “bugs".

View this Issue
Olga Anczukow and Ryan Englander discuss how transcriptome splicing affects immune system function in lung cancer.

Long-Read RNA Sequencing Reveals a Regulatory Role for Splicing in Immunotherapy Responses

Pacific Biosciences logo
Research Roundtable: The Evolving World of Spatial Biology

Research Roundtable: The Evolving World of Spatial Biology

Conceptual cartoon image of gene editing technology

Exploring the State of the Art in Gene Editing Techniques

Bio-Rad
Conceptual image of a doctor holding a brain puzzle, representing Alzheimer's disease diagnosis.

Simplifying Early Alzheimer’s Disease Diagnosis with Blood Testing

fujirebio logo

Products

Eppendorf Logo

Research on rewiring neural circuit in fruit flies wins 2025 Eppendorf & Science Prize

Evident Logo

EVIDENT's New FLUOVIEW FV5000 Redefines the Boundaries of Confocal and Multiphoton Imaging

Evident Logo

EVIDENT Launches Sixth Annual Image of the Year Contest

10x Genomics Logo

10x Genomics Launches the Next Generation of Chromium Flex to Empower Scientists to Massively Scale Single Cell Research