The 0.1% Portrait of Human History

Stored in the human genome, perhaps, is the record of human evolution and existence on this planet. Many say, however, that this history and the benefits it may unfold for human health cannot be found in the single, essentially complete human sequence--99.9% similar to any other human sequence. It's the 0.1% difference that should tell the tale--not only of migration, war, technological achievement, and conquest--but also of the differences that confer susceptibility to complex, multigenic dis

Written byBrendan Maher
| 7 min read

Register for free to listen to this article
Listen with Speechify
0:00
7:00
Share

Stored in the human genome, perhaps, is the record of human evolution and existence on this planet. Many say, however, that this history and the benefits it may unfold for human health cannot be found in the single, essentially complete human sequence--99.9% similar to any other human sequence. It's the 0.1% difference that should tell the tale--not only of migration, war, technological achievement, and conquest--but also of the differences that confer susceptibility to complex, multigenic diseases.

In piecing together the travails of diverse human populations, geneticists use a growing number of tools and technologies. But, what would arguably be the most valuable resource to population geneticists still does not exist. First envisioned a decade ago, a project to sample diverse populations on a global scale faltered in its planning stages amid controversy and criticism that its proponents were not sensitive to the concerns of groups it proposed to study. Its ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!
Already a member? Login Here

Meet the Author

Published In

Share
Illustration of a developing fetus surrounded by a clear fluid with a subtle yellow tinge, representing amniotic fluid.
January 2026

What Is the Amniotic Fluid Composed of?

The liquid world of fetal development provides a rich source of nutrition and protection tailored to meet the needs of the growing fetus.

View this Issue
Human-Relevant In Vitro Models Enable Predictive Drug Discovery

Advancing Drug Discovery with Complex Human In Vitro Models

Stemcell Technologies
Redefining Immunology Through Advanced Technologies

Redefining Immunology Through Advanced Technologies

Ensuring Regulatory Compliance in AAV Manufacturing with Analytical Ultracentrifugation

Ensuring Regulatory Compliance in AAV Manufacturing with Analytical Ultracentrifugation

Beckman Coulter Logo
Skip the Wait for Protein Stability Data with Aunty

Skip the Wait for Protein Stability Data with Aunty

Unchained Labs

Products

Sino Biological Logo

Sino Biological's Launch of SwiftFluo® TR-FRET Kits Pioneers a New Era in High-Throughout Kinase Inhibitor Screening

SPT Labtech Logo

SPT Labtech enables automated Twist Bioscience NGS library preparation workflows on SPT's firefly platform

nuclera logo

Nuclera eProtein Discovery System installed at leading Universities in Taiwan

Brandtech Logo

BRANDTECH Scientific Introduces the Transferpette® pro Micropipette: A New Twist on Comfort and Control