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EDITOR'S CHOICE IN GENETICS & GENOMICS
K. Akagi et al., “Genome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability,” Genome Research, doi:10.1101/gr.164806.113, 2013.
Human papillomavirus (HPV) is known to promote mutations in its host’s DNA, though exactly how the virus contributes to genomic instability has been unclear. Researchers led by Maura Gillison of Ohio State University Comprehensive Cancer Center now show in human cancer cell lines and tumors that the sites where HPV integrates into the host genome are linked with genetic damage that may disrupt tumor suppressors and oncogenes.
“We [found] tremendous host genomic rearrangements happening immediately adjacent to the sites of the viral integration,” including deletions, amplifications, inversions, and even a case of chromosomal...