Cover Story

Pain and Progress
Pain and Progress
Kerry Grens | Feb 1, 2014
Is it possible to make a nonaddictive opioid painkiller?

Features

Brains in Action
Brains in Action
The Scientist Staff | Feb 1, 2014
Neuroscientists are automating neural imaging and recording, allowing them to monitor increasingly large swaths of the brain in living, behaving animals.
 
Syphilis: Then and Now
Syphilis: Then and Now
Kristin N Harper, George J. Armelagos, Molly K. Zuckerman | Feb 1, 2014
Researchers are zeroing in on the origin of syphilis and related diseases, which continue to plague the human population some 500 years after the first documented case.

Contributors

Contributors
Contributors
Contributors
Meet some of the people featured in the February 2014 issue of The Scientist.

Editorial

An Offensive Playbook
An Offensive Playbook
An Offensive Playbook
Developing nonaddictive drugs to combat pain

Speaking of Science

Speaking of Science
Speaking of Science
Speaking of Science
February 2014's selection of notable quotes

Notebook

Feeling Is Believing
Feeling Is Believing
Feeling Is Believing
Many people can “see” their hands in complete darkness, absent any visual stimulus, due to kinesthetic feedback from their own movements.
Self-Improvement Through the Ages
Self-Improvement Through the Ages
Self-Improvement Through the Ages
A 50,000-generation-long experiment shows that bacteria keep getting fitter.
Tenacious Termites
Tenacious Termites
Tenacious Termites
Formosan subterranean termites evade deadly pathogens by building nests lined with their own feces.
The Necrobiome
The Necrobiome
The Necrobiome
Next-generation sequencing of the bacterial assemblages that inhabit a corpse throughout decomposition improve time-of-death estimates.

Critic at Large

On Race and Medicine
On Race and Medicine
On Race and Medicine
Until health care becomes truly personalized, race and ethnicity will continue to be important clues guiding medical treatments.
What Women Need to Succeed in Science
What Women Need to Succeed in Science
What Women Need to Succeed in Science
Attracting females to research careers—and keeping them there

Modus Operandi

Visualizing Viruses
Visualizing Viruses
Visualizing Viruses
Scientists devise a gentler technique for observing viral DNA at single-molecule resolution.

The Literature

Epigenetics of Regeneration
Epigenetics of Regeneration
Epigenetics of Regeneration
Repairing damaged neurons relies on booting a histone deacetylase out of the nucleus so regeneration genes can be turned on.
Protein Function Refuted
Protein Function Refuted
Protein Function Refuted
A mouse knockout calls into question the presumed function of a protein long considered important for steroid hormone biosynthesis.
HPV Havoc
HPV Havoc
HPV Havoc
Human papillomavirus promotes genomic damage by inserting near host genes involved in cancer.

Profile

Meiosis Maven
Meiosis Maven
Meiosis Maven
Fueled by her love of visual data and addicted to chromosomes, Abby Dernburg continues to study how homologous chromosomes find each other during gamete formation.

Scientist to Watch

Phil Baran: Molecule Magician
Phil Baran: Molecule Magician
Phil Baran: Molecule Magician
Professor, Chemistry, The Scripps Research Institute. Age: 36

Lab Tools

Unmasking Secret Identities
Unmasking Secret Identities
Unmasking Secret Identities
A tour of techniques for measuring DNA hydroxymethylation
Tag, You're It
Tag, You're It
Tag, You're It
A guide to DNA-encoded libraries for drug discovery

Careers

New School
New School
New School
Graduate programs at the interface of quantitative and biological sciences set the stage for more interdisciplinary collaboration.
 

Reading Frames

When Buddhism Meets Biology
When Buddhism Meets Biology
When Buddhism Meets Biology
Can practitioners of the Eastern religion learn from biologists, or vice versa?

Capsule Reviews

Capsule Reviews
Capsule Reviews
Capsule Reviews
Me, Myself, and Why, RedDevil 4, Neanderthal Man, and Science from Sight to Insight

Foundations

Palade Particles, 1955
Palade Particles, 1955
Palade Particles, 1955
Electron microscopy led to the first identification of what would later be known as ribosomes.