Time to Abandon the Three Rs

Submitting to ?refinement, reduction, and replacement? risks the future of animal research

Written byStuart W.G. Derbyshire
| 3 min read

Register for free to listen to this article
Listen with Speechify
0:00
3:00
Share

The best hopes to treat or cure any number of diseases all rely on current animal experiments. Like all science, the investigations that scientists perform with animals increase our knowledge of nature and can therefore increase the possibilities for human action, advancing the cause of human freedom. So why do scientists persist in denigrating their own behavior by advocating the three Rs: refinement, reduction, and replacement?

In the United Kingdom, since the passage of the 1986 Animals (Scientific Procedures) Act, researchers must obtain a license from the Home Office, which involves an assessment of the invasiveness of the study and the species used, following the principles of the three Rs. Invariably, licensing will require considerable justification for any procedures that involve distressing the animal, and considerable pressure will be applied for the use of fewer animals, and from further down the phylogenetic tree (such as using rats rather than primates). ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!
Already a member? Login Here

Meet the Author

Published In

Share
Image of small blue creatures called Nergals. Some have hearts above their heads, which signify friendship. There is one Nergal who is sneezing and losing health, which is denoted by minus one signs floating around it.
June 2025, Issue 1

Nergal Networks: Where Friendship Meets Infection

A citizen science game explores how social choices and networks can influence how an illness moves through a population.

View this Issue
Illustrated plasmids in bright fluorescent colors

Enhancing Elution of Plasmid DNA

cytiva logo
An illustration of green lentiviral particles.

Maximizing Lentivirus Recovery

cytiva logo
Explore new strategies for improving plasmid DNA manufacturing workflows.

Overcoming Obstacles in Plasmid DNA Manufacturing

cytiva logo
Unraveling Complex Biology with Advanced Multiomics Technology

Unraveling Complex Biology with Five-Dimensional Multiomics

Element Bioscience Logo

Products

The Scientist Placeholder Image

Waters Enhances Alliance iS HPLC System Software, Setting a New Standard for End-to-End Traceability and Data Integrity 

The Scientist Placeholder Image

Agilent Unveils the Next Generation in LC-Mass Detection: The InfinityLab Pro iQ Series

agilent-logo

Agilent Announces the Enhanced 8850 Gas Chromatograph

parse-biosciences-logo

Pioneering Cancer Plasticity Atlas will help Predict Response to Cancer Therapies