In the Early Edition of the
The authors showed that comparative gene-expression profiling might be used to gain insights into gene function. Expression in specific tissues also gives clues about possible physiological function or regulation. For example, they were able to find pituitary-specific genes that may be regulated by the Pit1 transcription factor; they also found genes implicated in disease states, such as prostate cancer.
The mouse and human transcriptomes can be compared...