Courtesy of Ronald Simon, University of Basel
Barely five years ago, Juha Kononen, then at the National Cancer Institute, presented a straightforward way of constructing tissue microarrays (TMAs): a glass slide covered with as many as 1,000 cores of tissue, measuring from 0.6 mm to 2.0 mm in diameter.1 Suddenly, researchers could analyze gene expression and protein levels on hundreds of tissue samples by processing just one slide, instead of the hundreds previously required. As a result, scientists can better validate molecular markers of both development and disease.
As with many burgeoning fields, new users of TMAs find many options but little guidance in making a purchasing decision.
A variety of factors ...
