1. Piston proton pump » The X-ray structure of a membrane complex involved in aerobic respiration (and implicated in neurodegeneration) reveals an unusual piston-like mechanism for pumping protons across the mitochondrial membrane, and provides clues for developing drugs against Parkinson’s and other related diseases.
R.G. Efremov et al., Nature, 2010 May 27, 465(7297):441–45. Eval by Nathan Nelson, Tel Aviv Univ; Andrea Mattevi, Univ Pavia; Terrence Frey, San Diego State Univ; Thomas Meier, Max Planck Institute of Biophysics ID: 3375956
2. A gene for autoimmunity » Defective sialic acid acetylesterase (SIAE)—an enzyme involved in the regulation of B lymphocyte signaling—infers a greater risk of autoimmune disorders, such as rheumatoid arthritis and type I diabetes, and may contribute to the pathogenesis of such diseases.
I. Surolia et al., Nature, AOP: 2010 June 16. Eval by Mark Anderson, Univ Calif, San Francisco; Anthony DeFranco, UCSF ID: 3611960
3. Super E. coli » The ...
