linkurl:1. Immune response feeds parasite;
Color-enhanced scanning electron micrograph showing Salmonella typhimurium (red) invading cultured human cells.
Image: Wikimedia commons, NIAID, NIH
Salmonella is able to outcompete resident gut microbes by deriving energy from the inflammatory immune response that is supposed to combat the pathogen. S.E. Winter, et al., "Gut inflammation provides a respiratory electron acceptor for Salmonella," linkurl:Nature,; 467:426-9, 2010. Evaluated by Matam Vijay-Kumar and Andrew Gewirtz, Emory University; David Alpers, Washington University School of Medicine; Alexei Kurakin and Roya Khosravi-Far, Beth Israel Deaconess Medical Center; Michael Hensel, University of Osnabrück; Yvonne Sun and Mary O'Riordan, University of Michigan Medical School; Wolf-Dietrich Hardt, Swiss Federal Institute of Technology; James Moir, University of York; Victor Nizet, University of California, San Diego. linkurl:Free F1000 evaluation; linkurl:2. Piezos for pain; A family of proteins, called Piezos, may be components of mechanically activated ion channels which make possible several senses, such...
B. Coste, et al., "Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels," linkurl:Science,; 330:55-60, 2010. Evaluated by M. Moran & D. Kimball, Hydra Biosciences; J. Garcia-Anoveros, Northwestern University; F. Viana, UMH Instituto de Neurociencias; P. Garrity, Brandeis Univ; B. Nilius, KU Leuven. linkurl:Free F1000 evaluation; U.A. Ørom, et al., "Long noncoding RNAs with enhancer-like function in human cells," linkurl:Cell,; 143(1):46-58, 2010. Evaluated by L. Ringrose, Inst of Molecular Biotechnology GmbH; A. Clery, Dominik Theler & F. Allain, ETH; J. Abrams, U of Texas Southwestern Med Cen at Dallas; H. Steinbeisser, Univ of Heidelberg; E. Lara-Pezzi & N. Rosenthal, EMBL. linkurl:Free F1000 evaluation; L. Warren, et al., "Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA," linkurl:Cell Stem Cell,; 7(5):618-30, 2010. Evaluated by R. Juliano, Univ North Carolina; B. Aranda-Orgilles & I. Aifantis, HHMI/NYU School of Med; K. Maass & G. Fishman, NYU Langone Med Cen; A. Kriegstein, UCSF. linkurl:Free F1000 evaluation; F. Wang, et al., "Histone H3 Thr-3 phosphorylation by Haspin positions Aurora B at centromeres in mitosis," linkurl:Science,; 2010 Aug 12 doi: 10.1126/science.1189435. Evaluated by W. Earnshaw, Univ of Edinburgh; E. Avvedimento, Univ Federico II; S. Ems-McClung & C. Walczak, Indiana Univ; R. Medema, Univ. Med Cen Utrecht, Netherlands; K. Lee, NIH. linkurl:Free F1000 evaluation; G.D. Field, et al., "Functional connectivity in the retina at the resolution of photoreceptors," linkurl:Nature,; 467:673-7, 2010. Evaluated by Richard Born, Harvard Medical School; Bruce Cumming, NEI; Christina Joselevitch and David Zenisek, Yale University School of Medicine; David P Wolfer, University of Zurich. linkurl:Free F1000 evaluation; R.B. Deal and S. Henikoff, "A simple method for gene expression and chromatin profiling of individual cell types within a tissue," linkurl:Dev Cell,; 18:1030-40, 2010. Evaluated by E.S. Dennis, CSIRO; E. Lam, Rutgers Univ; D. Chamovitz, Tel Aviv Univ; K. Schneitz, Technische Univ Munchen; P. Kaufman, U Mass Med School. linkurl:Free F1000 evaluation;

Interested in reading more?

Become a Member of

Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!