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linkurl:2. Drug helps - not hurts - in serious lung disease;http://f1000.com/5240957?key=09p5z453y7rgx27 Doctors have hesitated to give neuromuscular blocking agents to patients with the life-threatening lung condition called acute respiratory distress syndrome, out of fear the drugs could cause muscle weakness. But a clinical trial found patients who took a neuromuscular blocker were more likely than those on a placebo to survive 90 days, and showed no increase in muscle weakness. (Some faculty members, however, disagreed with the paper's conclusions, arguing narcotics are more appropriate in these patients.) L. Papazian et al, linkurl:N Engl J Med,;http://www.ncbi.nlm.nih.gov/sites/entrez/20843245?dopt=Abstract&holding=f1000%2Cf1000m 363:1107-16, 2010. Evaluated by M. Gropper, University of California, San Francisco; R. Basner, Columbia University College of Physicians and Surgeons; J. Sellares and A. Torres, Hospital Clinic de Barcelona; M. Gama de Abreu, Clinic Carl Gustav Carus; J. Neely & A. Vuylsteke, Papworth Hospital; G. Martin, Emory University; M. O'Connor, University of Chicago; P. Fassbender & M. Eikermann, Massachusetts General Hospital. linkurl:Free F1000 Evaluation;http://f1000.com/5240957?key=09p5z453y7rgx27 linkurl:3. Early palliative care helps in advanced cancer;http://f1000.com/4929959?key=rnr30w57fzggfr9 Patients with inoperable, metastatic non-small-cell lung cancer may benefit from early palliative care, reporting a better quality of life, and less depression than those who did not receive palliative care. Median survival also improved in those receiving early palliative care, even though they were less likely to receive aggressive treatment at the end of their lives. J.S. Temel et al, linkurl:N Engl J Med,;http://www.ncbi.nlm.nih.gov/sites/entrez/20818875?dopt=Abstract&holding=f1000%2Cf1000m 363:733-42, 2010. Evaluated by F. Ajaz and R. ZuWallack, St Francis Hospital; D. Spiegel, Stanford University School of Medicine; P. Lee, National University Hospital, Singapore; M. Rodin, St. Louis University Medical School; N. Chao, Duke University Medical Center; H. Klepin, Wake Forest University School of Medicine. linkurl:Free F1000 Evaluation;http://f1000.com/4929959?key=rnr30w57fzggfr9 linkurl:4. Key element of bone marrow stem cell niche spotted;http://f1000.com/5000965?key=5mmh4nn1nxs57yh Researchers have struggled to characterize the cellular components of the hematopoietic stem cell niche in bone marrow, but one has been newly pegged: the other bone marrow stem cell (mesenchymal stem cell), capable of differentiating into cartilage- and bone-forming cells, appears to organize and regulate the stem cell niche in bone marrow, the authors note. S. Mendez-Ferrer, linkurl:Nature,;http://www.ncbi.nlm.nih.gov/sites/entrez/20703299?dopt=Abstract&holding=f1000%2Cf1000m 466:829-34, 2010. Evaluated by Y. Pang & T. Cheng, University of Pittsburgh; N. Bazhanov & D. Prockop, Texas A&M Health Sciences Center; M. Riminucci & P. Bianco, University of Rome "La Sapienza"; Y. Matsumoto and T. Suda, Keio University. linkurl:Free F1000 Evaluation;http://f1000.com/5000965?key=5mmh4nn1nxs57yh linkurl:5. Genes behind patchy hair loss;http://f1000.com/3732956?key=50b2gkjjr8txj67 A genome-wide association study provides clues to the mysterious pathogenesis of alopecia areata (AA), a common autoimmune disease in which hair falls out in patches, affecting an estimated 2 percent of the population. The paper reveals more than 100 SNPs associated with AA, involved in both innate and adaptive immunity. L. Petukhova et al, linkurl:Nature,;http://www.ncbi.nlm.nih.gov/sites/entrez/20596022?dopt=Abstract&holding=f1000%2Cf1000m 466:113-7, 2010. Evaluated by S. Inui & S. Itami, Osaka University; Y. Ramot & A. Zlotogorski, Hadassah-Hebrew University Medical Center; R. Sinclair, University of Melbourne. linkurl:Free F1000 Evaluation;http://f1000.com/3732956?key=50b2gkjjr8txj67 linkurl:6. Don't wake me, please;http://f1000.com/4713956?key=8y2qtb133rglx2s The brain doesn't passively transition between consciousness and unconsciousness during anesthesia, based simply on how much of the drug is present, as previously thought, a new study in mice and Drosophila reports. These findings suggest the brain has a tendency to resist such transitions, and may provide insights in sleep regulation and disorders. E.B. Friedman et al, linkurl:PLoS One,;http://www.ncbi.nlm.nih.gov/sites/entrez/20689589?dopt=Abstract&holding=f1000%2Cf1000m 5(7):e11903, 2010. Evaluated by M. Perouansky, University of Wisconsin; E. Whitlock & M. Avidan, Washington University; M. Sahinovic & A. Absalom, University Medical Center Groningen. linkurl:Free F1000 Evaluation;http://f1000.com/4713956?key=8y2qtb133rglx2s linkurl:7. Pain relief for the addicted;http://f1000.com/5007957?key=3bwkwml2g597tz0 In patients with a dependence on opiates, pain relief is tough to achieve, but those who received ketamine, an N-methyl-d-aspartate receptor antagonist, with anesthesia during back surgery reported less pain and needed less morphine during recovery. R.W. Loftus, et al, linkurl:Anesthesiology,;http://www.ncbi.nlm.nih.gov/sites/entrez/20693876?dopt=Abstract&holding=f1000%2Cf1000m 113:639-46, 2010. Evaluated by C. Rivat & P. Richebe, University of Washington; L. Le-Wendling & A. Boezaart, University of Florida College of Medicine; A. Barreveld & D. Correll, Brigham & Women's Hospital; A. Lynn, Children's Hospital, Seattle; D. Gupta, Feinberg School of Medicine Northwestern University. linkurl:Free F1000 Evaluation;http://f1000.com/5007957?key=3bwkwml2g597tz0 The F1000 Top 7 is a snapshot of the highest ranked articles from a 30-day period on Faculty of 1000 Medicine, as calculated on November 11, 2010. Faculty Members evaluate and rate the most important papers in their field. To see the latest rankings, search the database, and read daily evaluations, visit http://f1000.com.
**__Related stories:__***linkurl:Top 7 hidden jewels;http://www.the-scientist.com/news/display/57789/
[26th October 2010] *linkurl:Top 7 papers in biochemistry;http://www.the-scientist.com/news/display/57753/
[19th October 2010] *linkurl:Top 7 papers in neuroscience;http://www.the-scientist.com/news/display/57800/
[9th November 2010]
