A.L. Cox, J. Skipper, Y. Chen, R.A. Henderson, T.L. Darrow, J. Shabanowitz, V.H. Engelhard, D.F. Hunt, C.L. Slingluff, "Identification of a peptide recognized by five melanoma-specific human cytotoxic T cell lines," Science, 264:716-9, 1994. (Cited in more than 60 articles through September 1995)
Comments by Victor Engelhard, University of Virginia, Charlottesville
The importance of this paper, according to Victor Engelhard, a professor of microbiology at the University of Virginia, is that "it was one of the first conclusive reports describing a specific tumor antigen to be recognized by cytotoxic T cells in humans.
PINPOINTING PEPTIDES: Victor Engelhard's team identified a tumor antigen specific to melanoma cells.
Subsequently, notes Engelhard, "Craig Slingluff and others showed that cytotoxic T cells isolated from one melanoma patient could recognize melanoma tumors from other patients as long as the patients shared at least one MHC-major histocompatibility complex-molecule with the [source] patient [T.L. Darrow et al., ...
