Zeroing in on the “Gay Gene”

The largest study yet of the genetic roots of homosexuality links sexual preference in men to two regions of the genome.

Written byBob Grant
| 2 min read

Register for free to listen to this article
Listen with Speechify
0:00
2:00
Share

© ALEKSANDAR STOJKOVIC/SHUTTERSTOCKAt least in men, homosexuality may be a function of genetics, according to a study of more than 400 pairs of gay brothers. The research, published yesterday (November 18) in Psychological Medicine, confirms the role of a stretch of the X chromosome in determining sexual preference in men, a finding first suggested more than 20 years ago. Geneticist Dean Hamer, scientist emeritus at the National Institutes of Health, published a study in 1993 that proposed that Xq28, a region of the X chromosome, might play a role in determining whether a man was gay. “When you first find something out of the entire genome, you’re always wondering if it was just by chance,” Hamer told Science of the new study, adding that the research “clarifies the matter absolutely.”

Hamer, who recently wrote an opinion piece in The Scientist about the responsibilities of researchers who study sexual orientation, only studied 38 pairs of brothers in his 1993 study, but he told New Scientist that he sees the new paper as confirmation of his work. “Twenty years is a long time to wait for validation, but now it’s clear the original results were right,” he said. “It’s very nice to see it confirmed.”

But as was the case in 1993, not all researchers are convinced that science is homing in on the biological roots of sexual preference. Even the senior author on the Psychological Medicine paper, Northwestern University psychologist Michael Bailey, had his doubts. “I thought that [Hamer] did a fine but small study,” he ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member? Login Here

Related Topics

Meet the Author

  • From 2017 to 2022, Bob Grant was Editor in Chief of The Scientist, where he started in 2007 as a Staff Writer. Before joining the team, he worked as a reporter at Audubon and earned a master’s degree in science journalism from New York University. In his previous life, he pursued a career in science, getting a bachelor’s degree in wildlife biology from Montana State University and a master’s degree in marine biology from the College of Charleston in South Carolina. Bob edited Reading Frames and other sections of the magazine.

    View Full Profile
Share
Illustration of a developing fetus surrounded by a clear fluid with a subtle yellow tinge, representing amniotic fluid.
January 2026, Issue 1

What Is the Amniotic Fluid Composed of?

The liquid world of fetal development provides a rich source of nutrition and protection tailored to meet the needs of the growing fetus.

View this Issue
Skip the Wait for Protein Stability Data with Aunty

Skip the Wait for Protein Stability Data with Aunty

Unchained Labs
Graphic of three DNA helices in various colors

An Automated DNA-to-Data Framework for Production-Scale Sequencing

illumina
Exploring Cellular Organization with Spatial Proteomics

Exploring Cellular Organization with Spatial Proteomics

Abstract illustration of spheres with multiple layers, representing endoderm, ectoderm, and mesoderm derived organoids

Organoid Origins and How to Grow Them

Thermo Fisher Logo

Products

Brandtech Logo

BRANDTECH Scientific Introduces the Transferpette® pro Micropipette: A New Twist on Comfort and Control

Biotium Logo

Biotium Launches GlycoLiner™ Cell Surface Glycoprotein Labeling Kits for Rapid and Selective Cell Surface Imaging

Colorful abstract spiral dot pattern on a black background

Thermo Scientific X and S Series General Purpose Centrifuges

Thermo Fisher Logo
Abstract background with red and blue laser lights

VANTAstar Flexible microplate reader with simplified workflows

BMG LABTECH