A selected list of oncolytic viruses in clinical trials

Click on the company or institution name for more information on the clinical trials

Adenovirus E1B deletion restricts replication to cells with abberant mRNA transport Head and neck tumors Phase III Sunway Biotech of China (H101)
Head and neck tumors Phase III (canceled) Onyx (O15)
Coxsackie virus Targets DAF/intercellular adhesion molecule 1, which is overexpressed in cancer Stage IV melanoma Phase I Viralytics (A21)
Herpes simplex virus 1 ICP34.5 deletion restricts replication to cells with active replication Melanoma Phase II BioVex (OncoVEXGM-CSF)
Glioma, astrocytoma, glioblastoma Phase I/II MediGene (G207, NV1020)
Glioma, melanoma, squamous cell carcinoma of the head and neck Phase I/II Crusade Laboratories (HSV1716)
Measles virus Engineered to target CD46 on tumor cells Brain and central nervous system tumors Phase I Mayo Clinic (MV-CEA)
Newcastle disease virus Naturally unable to...

Interested in reading more?

Magaizne Cover

Become a Member of

Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!
Already a member?