Arthur C. Guyton, world-renown physiologist and author of the best-selling Textbook of Medical Physiology, died in an automobile accident in Mississippi April 3. He was 83.

Widely regarded as a pillar in the field of physiology, Guyton's lifelong study of the cardiovascular system resulted in three discoveries that changed the discipline. Another, perhaps equal, legacy lives on in the 150 scientists he helped to educate and train. Of those, 29 have become chairs of their own departments and six are former presidents of the American Physiological Society.

"His door was always open and he was never too busy to talk about a new research idea, a new experiment, or to talk with a student who was having difficulty," said John E. Hall, a former Guyton student who succeeded his mentor as chairman of the Department of Physiology and Biophysics at the University of Mississippi Medical Center. "He would...

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