Microarray analysis defines the 'telomerase deletion response' in the absence of telomere maintenance.

Microarrays experiments reveal changes in the mosquito transcriptome in response to infection and stress.

Genes induced by DNA-damaging agents appear not to be those required for survival.

Two mitochondrial proteins have been found to control transcription of mitochondrial DNA.

Operons contain multiple adjacent genes whose transcription is regulated by the transcription of a single polycistronic message. The processing of polycistronic pre-mRNA involves 3' end formation and trans-splicing by the specialized SL2 small nuclear ribonucleoprotein particle. In the June 20 Nature, Thomas Blumenthal and colleagues describe a screen for SL2-containing mRNAs in the Caenorhabditis elegans genome (Nature 2002, 417:851-854).Blumenthal et al. used a probe enriched for SL2-containin

A new map of the human genome has five times higher resolution than previous maps.

Experiments in fibroblasts have identified an enzyme that induces hypermutation resembling the hypermutator of immunoglobulin genes in lymphocytes.

strains led to the discovery of a pathogenicity island important in antibiotic resistance.

Fanconi Anemia (FA) is a recessive cancer susceptibility syndrome. Six FA genes have been cloned and encode proteins involved in a DNA-damage response pathway. In the June 13 ScienceXpress, Niall Howlett and colleagues report the characterization of mutations in cells from the FA subtypes B and D1 (ScienceXpress 2002, DOI:10.1126/science.1073834).They discovered biallelic mutations in the BRCA2 breast cancer susceptibility gene; the mutations create frameshifts resulting in truncated BRCA2 prote

Anopheles gambiae is the mosquito vector that is responsible for the transmission of malaria across Africa. In the June 11 Proceedings of the National Academy of Sciences, Dana Thomasová and colleagues report the sequencing of bacterial artificial chromosomes (BACs) covering over 500 kilobases from the Pen1 locus within the 8C region of A. gambiae chromosome 2R (Proc Natl Acad Sci USA 2002, 99:8179-8184).Sequence analysis led to the identification and annotation of 48 genes (46 encoding pro

A large complex of proteins containing U3 snoRNA and 28 functionally associated proteins has been purified and characterized.

Short interfering RNAs targeted at either host or viral genes may prevent HIV infection.