Many experiments in cell biology require researchers to break open cells and then retrieve their contents. For example, the production of recombinant proteins in biotechnology relies on cell and tissue cultures--and cell disruption is essential to retrieving sought-after cell products. The technology used must be powerful enough to disrupt cell membranes and, possibly, cell walls, yet gentle enough so that the organelles and macromolecules inside the cells are not smashed, shattered, or boiled

with the title of adjunct can vary greatly. An adjunct may be a professor in name only, lending the prestige of name recognition, but requiring no inclass time. This is the case for the National Institutes of Health's Robert Gallo, who is an adjunct professor at Cornell University in Ithaca, N.Y. Gallo "is listed as an adjunct professor of veterinary microbiology, immunology and parasitology, and . . . has an assigned office in the Veterinary Research Tower here, but a phone number that pro

AUTHOR: RICKI LEWIS, pp.18 In just over a decade, genetically engineered mice have brought dramatic changes to the biomedical sciences, offering basic researchers ways to detect the influences of single genes and more clinically oriented investigators compellingly close models of human disease. The following suppliers are among those providing transgenic and knockout mice to researchers. Charles River Laboratories 251 Ballardvale St. Wilmington, Mass. 01887 (508) 658-6000 Products: OncoM

ideas, loves teaching, is up to date in his or her field, and writes well need not expend much effort in finding a publisher--publishers do the finding. Scores of publishers' sales representatives fill the halls of academia every fall and spring, hawking their wares, but also carefully scouting for promising authors. Editors also come a-hunting. "I knock on doors, ask questions, and see if professors are interested in writing a text," says Ron Pullins, chemistry editor at West Publishi

The gene amplification technique invented by genetics researcher Kary Mullis on a moonlit drive through the northern California hills a decade ago--the polymerase chain reaction (PCR)-- continues to revolutionize the life sciences. Uses in molecular biology research and in diagnostic tests are proliferating, and PCR is even bringing a new molecular approach to such fields as paleontology and epidemiology. The following companies are among those supplying PCR-related products for the resear

With the pandemic mounting and no sure remedies in sight, experts foresee the growing recruitment of skilled researchers On May 21, the World Health Organization announced that 14 million people have been infected with HIV so far, and the global figure could hit 40 million by the year 2000. And the ninth international AIDS meeting in Berlin earlier this month yielded little startling information beyond the general agreement among scientists that they have been, in effect, stymied thus f

After a grueling search, the gene causing a disorder is identified. Now what? While hope for rapid development of a cure fixes itself in the public's mind, in the scientific sector, discovery of a health-related gene catalyzes a frenzy of research activity, geneticists say. The first steps following gene discovery have become somewhat routine: completing sequencing of the gene, matching the sequence to a known protein pattern (if possible), deciphering gene expression through tissue and ti

As molecular biology becomes increasingly informational, computer software to manipulate and analyze nucleic acid sequences has evolved from a useful tool to an absolute necessity, researchers say. Foster City, Calif. 94404 (800) 345-5ABI Fax: (415) 572-2743 Products: GENESCAN 672 for microsatellite markers on Macintosh: call for price. DNASTAR Inc. 1228 S. Park St. Madison, Wis. 53715 (608) 258-7420 Fax: (608) 258-7439 Products: Lasergene comprehensive package: $3,995; Lasergene options,

Smarter consumership and rigid demands from investors leave little room for fuzzy thinking in entrepreneurial plans Despite recent setbacks in drug approvals, the mounting campaign for cost-cutting in the health care industry, and ongoing tribulations in the United States and global financial markets, the domestic biotechnology startup world is apparently holding its own. As the industry at large matures, analysts say, new entrants are learning from the highly publicized mistakes of their pr

One way to combat future science phobia and illiteracy is to bring children closer to scientists, educators say. And because scientists often have many stories to tell, publishers have found that using them as authors of children's science books can help bring the excitement of research to youngsters with an authenticity and perspective that nonscientist-authors cannot easily convey. The secret of good writing is for the final product to look effortless. But writing a successful book requir

Interferons (IFs) and interleukins (ILs) are immune system biochemicals at the intersection of basic research and medical technology. Part of the class of secreted cellular regulators known as cytokines, IFs and ILs have experienced dizzying public relations ups and downs, hailed one season as tomorrow's wonder drugs, derided the next as toxic side effects emerge during therapy. type_Document_Title_here With many questions about the basic biology of these enigmatic immunochemicals stil

Companies discussed in the accompanying article: Bio-Rad Laboratories 2000 Alfred Nobel Dr. Hercules, Calif. 94547 (800) 4 - BIORAD Fax: (800) 879-2289 Products: Call for catalog BIO 101 Inc. 1060 Joshua Way Vista, Calif. 92083 (800) 424-6101 Fax: (619) 598-0116 Products: phage DNA isolation yeast transformation Geneclean DNA purification Mermaid oligomer purification RNaid RNA purification Circleprep plasmid preparation G nome DNA isolation, for genomic DNA BioWhittaker Inc. 8830 Biggs F