S. Mueller et al., "Interaction of the poliovirus receptor CD155 with the dynein light chain Tctex-1 and its implication for poliovirus pathogenesis," Journal of Biological Chemistry, 277:7897-904, March 8, 2002. "This paper provides a molecular mechanism for how poliovirus hijacks cellular retrograde transport machinery to ascend along axons. A clear exposition of poliovirus pathogenesis and a testable model." —Lynn Enquist, Princeton University, US Complement Enforcement M. Budayov

A little over a year ago, BioCrystal of Westerville, Ohio, introduced the futuristically designed OptiCell™ for tissue culture.1 The 100-cm2 growth area of each OptiCell (33% more than a T-75 flask) requires only 10 ml of growth medium. Building on this invention, BioCrystal developed a fully automated Robotic Cell Culture System (RC2S) capable of processing 402 OptiCells from inoculation to harvest with almost no human intervention. "Our focus is on growing anchorage-dependent cells," say

Definition of cellular structure and function is an ongoing challenge facing the research community, with the complexity multiplying each time a scientist announces the discovery of new proteins and pathways. The need for more, and better tools is met often on purpose, but sometimes by serendipity. Although Mikhail Matz and colleagues might dispute that their isolation of a red fluorescent protein from a nonbioluminescent marine animal (Discosoma sp.) was serendipitous, their hypothesis was, at