Botanists Ply Trade In Tropics, Seeking Plant-Based Medicinals

A renewed interest in ancient pharmaceuticals spurs debate over the extent to which natives should be compensated Lisa Conte, president of two-year-old Shaman Pharmaceuticals in San Carlos, Calif., needed a way for her company to find new therapeutic agents to compete with massive drug-screening efforts and biotechnology-based drug-discovery initiatives waged by the major pharmaceutical companies. The strategy she came up with was to look for leads from plant-based, non-Western medicines used

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Although all the clinical data aren't in yet, Conte's scientists succeeded in finding an antiviral agent derived from a medicinal plant used in South America that acts against respiratory viruses in vivo and in vitro. With a patent pending on the pure compound isolated from the plant, Conte hopes to start clinical trials later this summer. And Conte says she's already discussing licensing arrangements with some larger drug companies.

A notable recent development on the ethnobotanical front is creation of a jointly owned company established by Syntex Pharmaceuticals International Ltd. (SPIL) and the Hong Kong Institute of Biotechnology (HKIB) last April 15. The new company, HKIB/Syntex Ltd., will build a research facility in Hong Kong to screen synthetics and natural compounds based on traditional medicines for their potential as new drugs. Two research institutes of the Chinese Academy of Sciences in the will also participate in this venture. A collaboration ...

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