For this article, Laura DeFrancesco interviewed Ian Dunham, senior research fellow at the Sanger Centre, Welcome Trust, UK; Bruce Roe, a research professor of chemistry and biochemistry at the University of Oklahoma; and Michio Hirano, Florence Irving assistant professor of neurology at Columbia University College of Physicians and Surgeons. Data from the Web of Science (ISI, Philadelphia) show that Hot Papers are cited 50 to 100 times more often than the average paper of the same type and age.

I. Dunham et al., "The DNA sequence of human chromosome 22," Nature, 402:489-95, 1999. (Cited in 358 papers)

I. Nishino et al., "Thymidine phosphorylase gene mutations in MNGIE, a human mitochondrial disorder," Science, 283:689-92, 1999. (Cited in 75 papers)

It was but a mere 30 million bases of the 3 billion that make up the human genome, but at the time, it represented a major breakthrough. The sequence...

Interested in reading more?

Become a Member of

Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!
Already a member?