WIKIMEDIA, JACOB TOORNVLIET's 'THE SLEEPING WOMAN' Humans’ 24-hour circadian clock plays a leading role in glucose tolerance, according to a study published Moday (April 13) in PNAS. Researchers in Boston have found that, because of body’s circadian rhythm, human glucose tolerance is reduced during the evening hours, even when “day” and “night” times are experimentally reversed.
“In a prior [human] study, we found that when behavior cycles of feeding and sleeping are not in normal alignment with the internal body clock, that this negatively affects the regulation of blood sugar and especially glucose tolerance,” said neuroscientist Frank Scheer from the Division of Sleep and Circadian Disorders at the Brigham and Women’s Hospital in Boston. People who work night shifts are more prone to type 2 diabetes and obesity, he noted.
In an attempt to understand the independent effects of eating and sleeping behaviors versus the circadian clock on glucose tolerance, Scheer and his colleagues mimicked night-shift work in 14 healthy individuals under controlled laboratory conditions. Participants spent eight days on a typical day-shift schedule, eating breakfast at 8:00 a.m., dinner at ...
