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The face of a young woman and the face of an old man surrounded by mechanical clocks.
Daily Gene Expression Rhythms Vary with Sex and Age: Study
By studying tissues from deceased people, a team found that women have more rhythmical gene expression and that this molecular rhythmicity decreases with age.
Daily Gene Expression Rhythms Vary with Sex and Age: Study
Daily Gene Expression Rhythms Vary with Sex and Age: Study

By studying tissues from deceased people, a team found that women have more rhythmical gene expression and that this molecular rhythmicity decreases with age.

By studying tissues from deceased people, a team found that women have more rhythmical gene expression and that this molecular rhythmicity decreases with age.

circadian clocks
A Nile rat sitting atop fruits
Genome Spotlight: Nile Rat (Avicanthis niloticus)
Christie Wilcox, PhD | Nov 23, 2022 | 4 min read
A reference sequence for this emerging model organism will facilitate research on type 2 diabetes and the health effects of circadian rhythm disruption.
Newborn baby rats lie in a basket
Mother’s Circadian Rhythms Mirrored in Fetal Rat Brains
Bianca Nogrady | Sep 12, 2022 | 2 min read
Before their own central clocks develop, the brains of fetal rats detect their mother’s metabolic cycle to help regulate the expression of certain genes.
Linking Biological Clocks and Cancer Therapeutics to Minimize Toxicity
It’s All in the Timing: Optimizing Chemotherapy Administration
Sejal Davla, PhD | 1 min read
How the biological clock influences chemotherapy success
Fluorescent microscopy of a healthy intestinal organoid and a tumor spheroid
Internal Clock Disruptions Increase Colon Cancer Risk in Mice
Shafaq Zia | Aug 19, 2022 | 3 min read
Disturbing circadian rhythms in organoids and mice increases intestinal tumor growth, findings that may explain a recent rise in colon cancer among young adults, the researchers behind the work say.
Segmented filamentous bacteria artificially colored in green attach to the intestinal wall of a mouse
Gut Microbes Help Coordinate Immune Activity in Mice
Catherine Offord | Jul 29, 2021 | 4 min read
The microbiota helps align a mouse’s innate immune system with its feeding patterns, prepping the animal to fend off infection when it’s most likely to be eating.
illustration of multiple clocks arranged in the shape of a brain
How Early-Morning Light Exposure Makes Mice Less Depressed
Bianca Nogrady | Jul 22, 2021 | 4 min read
A light-sensitive gene involved in regulating the body clock may also influence mood, mediating the effect of light.
Malaria Parasites’ Biological Clocks Coordinate Cell Destruction
Abby Olena, PhD | May 14, 2020 | 3 min read
Two studies show that Plasmodium—the genus of protozoans that cause malaria—have an internal sense of time that synchronizes with their host’s circadian rhythms and allows the parasites to collectively attack blood cells.
Light Enables Long-Term Memory Maintenance in Fruit Flies
Diana Kwon | May 1, 2020 | 2 min read
Under constant darkness, Drosophila’s ability to form lasting memories is impaired.
Into the Light: A Profile of Joanne Chory
Emily Makowski | Mar 1, 2020 | 8 min read
The plant geneticist has revolutionized researchers’ understanding of how light affects plant growth and development, and is engineering plants to combat climate change.
Circadian Clock Genes Help a Crop Pest Adapt to Climate Change
Emily Makowski | Jan 13, 2020 | 3 min read
As global temperatures rise and winters shorten, caterpillars of the corn borer moth are emerging earlier in parts of the US thanks to changes in two genes, researchers find.
circadian clock microbiome hdac3 histone deacetylation acetylation epigenetics gene expression metabolism fat lipid intestine gut
Microbes Shape Circadian Rhythms in the Mouse Gut
Kerry Grens | Sep 27, 2019 | 2 min read
The diurnal cycles of the microbiome alter the activity of a protein produced by the host, and in turn guide histone acetylation, gene expression, and metabolic activity.
a plate with fruits and vegetables arranged into the shape of a clock
People at Rest Burn More Calories in the Afternoon
Shawna Williams | Nov 8, 2018 | 2 min read
Circadian rhythms heavily influence how our bodies use energy, a small study suggests.
Infographic: The Role of Circadian Clocks in Muscle
Diana Kwon | Sep 1, 2018 | 2 min read
Timekeepers in muscle help mediate metabolism, and may influence neurological processes such as sleep.
Muscle Clocks Play a Role in Regulating Metabolism
Diana Kwon | Sep 1, 2018 | 9 min read
Just 20 years ago, scientists didn’t even realize muscles had their own circadian clocks. Now they are beginning to appreciate their importance in health. 
Limited Meal Times Prevent Obesity in Mice Prone to Gaining Weight
Abby Olena, PhD | Aug 30, 2018 | 3 min read
Even in mice with a busted circadian clock and an unhealthy diet, carefully timed feeding overcomes the rodents’ predispositions for metabolic diseases.
Fly’s Blood-Brain Barrier Has Circadian Rhythms
Abby Olena, PhD | Mar 8, 2018 | 3 min read
In Drosophila, the tissue is more permeable to drugs at night, offering a possible explanation for why some medicines work better at certain times of day.
Why Afternoon Open Heart Surgery Is Better for Patient Outcomes
Catherine Offord | Oct 27, 2017 | 2 min read
Research in human patients and mice reveals the role of the circadian clock in the risk of heart damage at different times of day.
Circadian Gene Linked to Severe Epilepsy in Children
Diana Kwon | Oct 11, 2017 | 3 min read
Loss of the CLOCK protein, which researchers find is decreased in pediatric epilepsy patients, makes mice more prone to seizures during sleep.
Q&A with Michael Young, Nobel Laureate
Ashley P. Taylor | Oct 2, 2017 | 5 min read
Young talks with The Scientist about studying circadian rhythms in fruit flies, the applications of his work beyond Drosophila, and winning the prize. 
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