Clock Reset on Denisovan-Neanderthal Split

Nuclear DNA from 430,000-year-old specimens indicates that Neanderthals had already diverged from their ancient-human predecessors.

Written byKerry Grens
| 1 min read

Register for free to listen to this article
Listen with Speechify
0:00
1:00
Share

WIKIPEDIA, JOSE-MANUEL BENITO ALVAREZThe collection of ancient-human remains at the Sima de los Huesos cave in Spain has led scientists to rewrite the timeline for human history—again. Using nuclear DNA extracted from the 430,000-year-old bones of two individuals, researchers determined that the bones belonged to Neanderthals, who must have split previously from the predecessor they share with Denisovans, another ancient-human group.

Earlier mitochondrial analyses of ancient DNA sourced from the site suggested the inhabitants were related to Denisovans, perhaps representing a common predecessor of Neanderthals and Denisovans.

In this latest study, published today (March 14) in Nature, Matthias Meyer of the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany, and colleagues examined nuclear DNA. The genetic material revealed that the bones were related to Neanderthals, and not Denisovans. However, Meyer and his colleagues wrote in their report, “mitochondrial DNA recovered from one of the specimens shares the previously described relationship to Denisovan mitochondrial DNAs, suggesting, among other possibilities, that the mitochondrial DNA gene pool of Neanderthals turned over later in their history.”

Chris Stringer, a palaeoanthropologist at the Natural History Museum in London, told Science ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member? Login Here

Related Topics

Meet the Author

  • kerry grens

    Kerry served as The Scientist’s news director until 2021. Before joining The Scientist in 2013, she was a stringer for Reuters Health, the senior health and science reporter at WHYY in Philadelphia, and the health and science reporter at New Hampshire Public Radio. Kerry got her start in journalism as a AAAS Mass Media fellow at KUNC in Colorado. She has a master’s in biological sciences from Stanford University and a biology degree from Loyola University Chicago.

    View Full Profile
Share
Illustration of a developing fetus surrounded by a clear fluid with a subtle yellow tinge, representing amniotic fluid.
January 2026, Issue 1

What Is the Amniotic Fluid Composed of?

The liquid world of fetal development provides a rich source of nutrition and protection tailored to meet the needs of the growing fetus.

View this Issue
Skip the Wait for Protein Stability Data with Aunty

Skip the Wait for Protein Stability Data with Aunty

Unchained Labs
Graphic of three DNA helices in various colors

An Automated DNA-to-Data Framework for Production-Scale Sequencing

illumina
Exploring Cellular Organization with Spatial Proteomics

Exploring Cellular Organization with Spatial Proteomics

Abstract illustration of spheres with multiple layers, representing endoderm, ectoderm, and mesoderm derived organoids

Organoid Origins and How to Grow Them

Thermo Fisher Logo

Products

Brandtech Logo

BRANDTECH Scientific Introduces the Transferpette® pro Micropipette: A New Twist on Comfort and Control

Biotium Logo

Biotium Launches GlycoLiner™ Cell Surface Glycoprotein Labeling Kits for Rapid and Selective Cell Surface Imaging

Colorful abstract spiral dot pattern on a black background

Thermo Scientific X and S Series General Purpose Centrifuges

Thermo Fisher Logo
Abstract background with red and blue laser lights

VANTAstar Flexible microplate reader with simplified workflows

BMG LABTECH