Cysteine Aids Mice with Huntington’s

Rodent models of Huntington’s disease show dysfunctional cysteine production, and adding the amino acid to their diets seems to relieve symptoms.

Written byKerry Grens
| 1 min read

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WIKIMEDIA, DR. STEVEN FINKBEINER

Scientists recently reported new insights into a possible molecular mechanism of Huntington’s disease and offered a potential route to correcting it. Experiments on mouse models of the neurodegenerative disease pointed to a dysfunction in the biosynthesis of the amino acid cysteine, and showed that supplementing their diets with cysteine seemed to reverse signs of the disease, according to a team led by researchers at the Johns Hopkins University School of Medicine. Their work was published in Nature last week (March 26).

“This is a very plausible theory (it seems to me), and the paper makes a very strong case for it,” Derek Lowe wrote at his blog, In The Pipeline.

Huntington’s researchers have long known the genetic culprit of the disease—a string of glutamines at ...

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  • kerry grens

    Kerry served as The Scientist’s news director until 2021. Before joining The Scientist in 2013, she was a stringer for Reuters Health, the senior health and science reporter at WHYY in Philadelphia, and the health and science reporter at New Hampshire Public Radio. Kerry got her start in journalism as a AAAS Mass Media fellow at KUNC in Colorado. She has a master’s in biological sciences from Stanford University and a biology degree from Loyola University Chicago.

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