Repurposed Drug Reverses Signs of Alzheimer’s in Mice, Human Cells
Repurposed Drug Reverses Signs of Alzheimer’s in Mice, Human Cells
Researchers say they hope to launch a clinical trial to test bumetanide, a diuretic approved in 2002, but how it might improve neural functioning is unclear.
Repurposed Drug Reverses Signs of Alzheimer’s in Mice, Human Cells
Repurposed Drug Reverses Signs of Alzheimer’s in Mice, Human Cells

Researchers say they hope to launch a clinical trial to test bumetanide, a diuretic approved in 2002, but how it might improve neural functioning is unclear.

Researchers say they hope to launch a clinical trial to test bumetanide, a diuretic approved in 2002, but how it might improve neural functioning is unclear.

neurodegeneration
Alzheimer’s Risk Gene Paradoxically Protects Against Memory Loss
Alzheimer’s Risk Gene Paradoxically Protects Against Memory Loss
Chloe Tenn | Oct 8, 2021
A new study links a variant of the apolipoprotein E gene called APOE ε4 to better memory in older age, even in the presence of amyloid plaques—a possible explanation for the variant’s persistence despite its association with an increased risk of Alzheimer’s disease.
Infographic: Modeling Neurodegenerative Diseases with Yeast
Infographic: Modeling Neurodegenerative Diseases with Yeast
Mahlon Collins | Oct 1, 2021
Conservation of structures and functions between single-celled fungi and human cells allow researchers to probe the brain.
Contributors
Contributors
The Scientist Staff | Oct 1, 2021
Meet some of the people featured in the October 2021 issue of The Scientist.
Yeast Models Provide New Insights into Neurodegenerative Diseases
Yeast Models Provide New Insights into Neurodegenerative Diseases
Mahlon Collins | Oct 1, 2021
The single-celled fungus allows researchers to study Alzheimer’s, Parkinson’s, ALS and other brain diseases with unparalleled speed and scale.
Biogen Defends Newly Approved Alzheimer’s Drug
Biogen Defends Newly Approved Alzheimer’s Drug
Jef Akst | Jul 27, 2021
The US Food and Drug Administration has called for a federal investigation of its own regulatory review process after widespread criticism of its decision on Aduhelm.
Updated
Biogen’s Alzheimer’s Drug Gets FDA Approval, Mixed Reviews
Biogen’s Alzheimer’s Drug Gets FDA Approval, Mixed Reviews
Kerry Grens | Jun 7, 2021
A lackluster performance in clinical trials of the monoclonal antibody aducanumab has left some experts unconvinced of its benefit.
Excerpt from <em>The Memory Thief</em>
Excerpt from The Memory Thief
Lauren Aguirre | Jun 1, 2021
Author Lauren Aguirre finds reasons for optimism in the fight against Alzheimer’s disease.
Sex of Human Cells Matters in Studying Neurological Disease
Sex of Human Cells Matters in Studying Neurological Disease
Amanda Heidt | Mar 18, 2021
Authors of a new review urge researchers to consider how the chromosomal sex of a cell affects experiments in research on neurodegeneration.
Eli Lilly Claims New Drug Can Slow Alzheimer&rsquo;s-Related Decline
Eli Lilly Claims New Drug Can Slow Alzheimer’s-Related Decline
Lisa Winter | Mar 16, 2021
Patients who received the drug fared better cognitively and functionally than those taking placebo, but still experienced losses in performance.
Reduced Adult Neurogenesis Linked with Alzheimer&rsquo;s Disease
Reduced Adult Neurogenesis Linked with Alzheimer’s Disease
Abby Olena | Feb 1, 2021
Manipulating the production of new neurons can improve cognition in animal models of the disease, raising the possibility that figuring out a way for humans to make more neurons could make a difference for people with dementia.
A Tweak to Immune Cells Reverses Aging in Mice
A Tweak to Immune Cells Reverses Aging in Mice
Abby Olena | Jan 20, 2021
Knocking out the receptor for a lipid that causes inflammation rejuvenates macrophage metabolism and restores cognitive function in an Alzheimer’s disease model.
Alzheimer&rsquo;s-Linked Mutation Causes Blockages in Neurons
Alzheimer’s-Linked Mutation Causes Blockages in Neurons
Ian Le Guillou | Nov 20, 2020
The variant causes a buildup of BACE1 protein in axons in cultured neurons and mice. Researchers say it might be time to rethink failed trials that inhibit BACE1 to treat the neurodegenerative disease.
First Alzheimer&rsquo;s Blood Test Rolled Out for Clinical Use in US
First Alzheimer’s Blood Test Rolled Out for Clinical Use in US
Shawna Williams | Nov 2, 2020
The test will be a cheaper and more accessible alternative to currently available diagnostic tools, researchers say.