Tiled blue-gray MRI readouts of a human brain.
Cancer Tied to Reduced Risk of Alzheimer’s Disease
Observational evidence for the connection is solidifying, and some clues are emerging about the mechanisms that may explain it.
ABOVE: © ISTOCK.COM, HAYDENBIRD
Cancer Tied to Reduced Risk of Alzheimer’s Disease
Cancer Tied to Reduced Risk of Alzheimer’s Disease

Observational evidence for the connection is solidifying, and some clues are emerging about the mechanisms that may explain it.

Observational evidence for the connection is solidifying, and some clues are emerging about the mechanisms that may explain it.

ABOVE: © ISTOCK.COM, HAYDENBIRD

neurodegeneration

Bespectacled man wearing black shirt with arms folded looks at camera in front of lab cabinet
Neuropathologist John Trojanowski Dies at 75
Lisa Winter | Mar 18, 2022
His work was pivotal to understanding the mechanisms of neurodegenerative diseases, particularly Alzheimer’s and Parkinson’s.
Image of brain cells showing pyramidal neurons in green, astrocytes in red, and microglia in blue
Replacing Microglia Treats Neurodegenerative Disease in Mice
Shawna Williams | Mar 17, 2022
Researchers find a way to wipe out the brain’s immune cell corps and send in new and improved versions.
Visualize Transcript Location with Spatial Biology Techniques
Unraveling the Cellular and Subcellular Landscape Using Spatial Biology
The Scientist Creative Services Team, Resolve Biosciences | Apr 12, 2022
How to visualize gene expression patterns in situ
Epstein-Barr virus EBV, a herpes virus which causes infectious mononucleosis and Burkitt's lymphoma isolated on black background. 3D illustration
Epstein-Barr Virus Causes Multiple Sclerosis: Study
Christie Wilcox | Jan 13, 2022
Experts say new research provides strong evidence that a common herpesvirus can trigger the chronic inflammatory disease.
Neuro collage
Our Favorite Neuroscience Stories of 2021
Chloe Tenn | Dec 29, 2021
From a Nobel prize and photosynthesis-powered brains to neurodegeneration research and controversy over a new Alzheimer’s drug, a look back at some of the biggest brain-related developments of the year.
Explore how scientists determine the atomic structures of protein aggregates
Revolutionizing Neurodegeneration Research with Cryo-EM
The Scientist Creative Services Team, Thermo Fisher Scientific | Feb 22, 2022
Advancements in cryo-EM technology allow researchers to develop drugs and diagnostic tools for neurodegenerative diseases.
A grid of images showing different cross sections of a human brain MRI.
Study Links Flu to Increased Parkinson’s Risk a Decade Later
Dan Robitzski | Nov 19, 2021
Epidemiological research suggests that a flu diagnosis might be one factor in the eventual onset of the neurodegenerative disease, but experts say it doesn’t prove a causal relationship.
An artist's rendition of an RNA molecule in light blue on a dark blue background
Same RNA Acts in Neurodegeneration and Cancer
Abby Olena | Oct 29, 2021
The long noncoding RNA MINCR, implicated in ALS and Alzheimer’s disease as well as several types of cancer, appears to function differently when present at high versus low levels.
Stem Cell Transplant Treats Parkinson’s Disease in Monkeys
Roni Dengler, PhD | Feb 7, 2022
Personalized stem cells improved motor symptoms and depression signs in monkeys modeling Parkinson’s disease, paving the way for trials in human patients.
Illustration of neurons in white with myelin in blue
Repurposed Drug Reverses Signs of Alzheimer’s in Mice, Human Cells
Jef Akst | Oct 12, 2021
Researchers say they hope to launch a clinical trial to test bumetanide, a diuretic approved in 2002, but how it might improve neural functioning is unclear.
Colored artistic rendition of neurons and plaque buildup
Alzheimer’s Risk Gene Paradoxically Protects Against Memory Loss
Chloe Tenn | Oct 8, 2021
A new study links a variant of the apolipoprotein E gene called APOE ε4 to better memory in older age, even in the presence of amyloid plaques—a possible explanation for the variant’s persistence despite its association with an increased risk of Alzheimer’s disease.
Melissa Vos discusses how lipids’ good intentions become harmful in Parkinson’s Disease
The Scientist Speaks - Lipids Predict a Slippery Path Towards Parkinson’s Disease
Nele Haelterman, PhD | Dec 14, 2021
Melissa Vos discusses how lipids’ good intentions become harmful in Parkinson’s Disease.
An illustration of a yeast cell (right) and a human neuron (left) showing the processes/features that are similar in the two
Infographic: Modeling Neurodegenerative Diseases with Yeast
Mahlon Collins | Oct 1, 2021
Conservation of structures and functions between single-celled fungi and human cells allow researchers to probe the brain.
Photographs of the October 2021 issue's contributors
Contributors
The Scientist Staff | Oct 1, 2021
Meet some of the people featured in the October 2021 issue of The Scientist.
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Using Digital Spatial Profiling for Transcriptomic Analysis of Neuronal Subpopulations
The Scientist Creative Services Team in collaboration with Advanced Cell Diagnostics | Nov 12, 2021
Kit Fuhrman and Anushka Dikshit present how to obtain whole transcriptome data from spatially mapped neuron populations.
Scanning electron micrograph (SEM) of the unicellular yeast Saccharomyces cerevisiae, known as Baker's or Brewer's yeast.
Yeast Models Provide New Insights into Neurodegenerative Diseases
Mahlon Collins | Oct 1, 2021
The single-celled fungus allows researchers to study Alzheimer’s, Parkinson’s, ALS and other brain diseases with unparalleled speed and scale.
A stamp with a checkmark and the word FDA approved lying on its side on a white background.
Biogen Defends Newly Approved Alzheimer’s Drug
Jef Akst | Jul 27, 2021
The US Food and Drug Administration has called for a federal investigation of its own regulatory review process after widespread criticism of its decision on Aduhelm.
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Metabolomic Links Between Environmental Exposures and Human Health
The Scientist Creative Services Team | Oct 25, 2021
Experts discuss how untargeted metabolomic studies connect environmental factors with human disease.
Updated
blue and white sign for the entrance to the FDA that says U.S. Department of Health and Human Services Food and Drug Administration
Biogen’s Alzheimer’s Drug Gets FDA Approval, Mixed Reviews
Kerry Grens | Jun 7, 2021
A lackluster performance in clinical trials of the monoclonal antibody aducanumab has left some experts unconvinced of its benefit.