Biogen Defends Newly Approved Alzheimer’s Drug
Biogen Defends Newly Approved Alzheimer’s Drug
The US Food and Drug Administration has called for a federal investigation of its own regulatory review process after widespread criticism of its decision on Aduhelm.
Biogen Defends Newly Approved Alzheimer’s Drug
Biogen Defends Newly Approved Alzheimer’s Drug

The US Food and Drug Administration has called for a federal investigation of its own regulatory review process after widespread criticism of its decision on Aduhelm.

The US Food and Drug Administration has called for a federal investigation of its own regulatory review process after widespread criticism of its decision on Aduhelm.

neurodegeneration
Understanding Microglial Response in Alzheimer’s Disease
Understanding Microglial Response in Alzheimer’s Disease
The Scientist Creative Services Team in collaboration with 10x Genomics | Jul 30, 2021
Single-cell technologies reveals subpopulations of microglia that play distinct roles in diseased and healthy brains.
Inhaled Antibody Fragments Protect Infected Animals Against COVID-19
Inhaled Antibody Fragments Protect Infected Animals Against COVID-19
Roni Dengler, PhD | Jun 14, 2021
Tiny but powerful nanobodies may be the innovation that snuffs out the pandemic.
Updated
Biogen’s Alzheimer’s Drug Gets FDA Approval, Mixed Reviews
Biogen’s Alzheimer’s Drug Gets FDA Approval, Mixed Reviews
Kerry Grens | Jun 7, 2021
A lackluster performance in clinical trials of the monoclonal antibody aducanumab has left some experts unconvinced of its benefit.
Excerpt from <em>The Memory Thief</em>
Excerpt from The Memory Thief
Lauren Aguirre | Jun 1, 2021
Author Lauren Aguirre finds reasons for optimism in the fight against Alzheimer’s disease.
Sex of Human Cells Matters in Studying Neurological Disease
Sex of Human Cells Matters in Studying Neurological Disease
Amanda Heidt | Mar 18, 2021
Authors of a new review urge researchers to consider how the chromosomal sex of a cell affects experiments in research on neurodegeneration.
Eli Lilly Claims New Drug Can Slow Alzheimer&rsquo;s-Related Decline
Eli Lilly Claims New Drug Can Slow Alzheimer’s-Related Decline
Lisa Winter | Mar 16, 2021
Patients who received the drug fared better cognitively and functionally than those taking placebo, but still experienced losses in performance.
Reduced Adult Neurogenesis Linked with Alzheimer&rsquo;s Disease
Reduced Adult Neurogenesis Linked with Alzheimer’s Disease
Abby Olena | Feb 1, 2021
Manipulating the production of new neurons can improve cognition in animal models of the disease, raising the possibility that figuring out a way for humans to make more neurons could make a difference for people with dementia.
A Tweak to Immune Cells Reverses Aging in Mice
A Tweak to Immune Cells Reverses Aging in Mice
Abby Olena | Jan 20, 2021
Knocking out the receptor for a lipid that causes inflammation rejuvenates macrophage metabolism and restores cognitive function in an Alzheimer’s disease model.
Alzheimer&rsquo;s-Linked Mutation Causes Blockages in Neurons
Alzheimer’s-Linked Mutation Causes Blockages in Neurons
Ian Le Guillou | Nov 20, 2020
The variant causes a buildup of BACE1 protein in axons in cultured neurons and mice. Researchers say it might be time to rethink failed trials that inhibit BACE1 to treat the neurodegenerative disease.
First Alzheimer&rsquo;s Blood Test Rolled Out for Clinical Use in US
First Alzheimer’s Blood Test Rolled Out for Clinical Use in US
Shawna Williams | Nov 2, 2020
The test will be a cheaper and more accessible alternative to currently available diagnostic tools, researchers say.
New Tracer Gives Clear Picture of Alzheimer&rsquo;s and Other Dementias
New Tracer Gives Clear Picture of Alzheimer’s and Other Dementias
Ian Le Guillou | Oct 29, 2020
An imaging agent reveals aggregated tau protein in the brain during PET scans and could improve the diagnosis of neurodegenerative diseases, particularly tauopathies.
The Scientist&#39;s LabTalk Podcast - Episode 2
The Scientist's LabTalk Podcast - Episode 2
The Scientist Creative Services Team | Oct 20, 2020
Surviving Stress: The mysteries of neuronal survival and neurodegeneration
Newly Found Alzheimer&rsquo;s Plaque Type Linked to Early-Onset Disease
Newly Found Alzheimer’s Plaque Type Linked to Early-Onset Disease
Ian Le Guillou | Sep 28, 2020
These “coarse-grained” plaques resemble those that clog up the brain’s blood vessels in a different disease, pointing to links between the vascular system and the neurodegenerative disease.
New Drug Combo for ALS Slows Decline in Small Clinical Study
New Drug Combo for ALS Slows Decline in Small Clinical Study
Jef Akst | Sep 3, 2020
After six months, patients with fast-progressing amyotrophic lateral sclerosis who had received the experimental treatment had less loss of function than those who received a placebo.
Neurobiologist Dave Schubert Dies
Neurobiologist Dave Schubert Dies
Kerry Grens | Aug 24, 2020
The Salk professor developed the institute’s first neurobiology lab and used it to develop cell lines, describe amyloid β toxicity, and screen for compounds that protect against neurodegeneration.
Experimental Blood Test Could Flag Alzheimer&rsquo;s
Experimental Blood Test Could Flag Alzheimer’s
Kerry Grens | Jul 29, 2020
New studies show that elevated levels of a form of tau called p-tau217 can accurately distinguish Alzheimer’s disease from other forms of dementia, and perhaps even predict it.
Flu and Pneumonia Vaccines Linked to Reduced Risk of Alzheimer&rsquo;s
Flu and Pneumonia Vaccines Linked to Reduced Risk of Alzheimer’s
Amanda Heidt | Jul 27, 2020
The authors propose that the shots might keep the immune system primed to battle diseases that would otherwise contribute to cognitive decline.
Astrocyte-to-Neuron Method Reverses Neurodegeneration in Mice
Astrocyte-to-Neuron Method Reverses Neurodegeneration in Mice
Ruth Williams | Jun 24, 2020
The cell conversion strategy restores neurons and motor functions lost as a result of an induced Parkinson’s-like illness in the animals.
RNAi Mechanisms in Neurodegenerative Disease Therapy
RNAi Mechanisms in Neurodegenerative Disease Therapy
The Scientist Creative Services Team | Jun 23, 2020
Experts will explore how RNAi mechanisms can modulate gene expression for the treatment of neurodegenerative diseases and how new methods for their use are being developed.