An illustration depicting pores on a membrane
DNA Nanopore Sequencing Adapted for Protein Sequence Comparisons
Researchers link a stretch of DNA to a peptide of interest and measure current changes as the molecule is pulled by a helicase through a nanopore.
ABOVE: © ISTOCK.COM, enot-poloskun
DNA Nanopore Sequencing Adapted for Protein Sequence Comparisons
DNA Nanopore Sequencing Adapted for Protein Sequence Comparisons

Researchers link a stretch of DNA to a peptide of interest and measure current changes as the molecule is pulled by a helicase through a nanopore.

Researchers link a stretch of DNA to a peptide of interest and measure current changes as the molecule is pulled by a helicase through a nanopore.

ABOVE: © ISTOCK.COM, enot-poloskun

amino acids

Illustration of a DNA-peptide conjugate molecule being pulled through a nanopore in a membrane.
Infographic: Reading Proteins with Nanopores
Sophie Fessl | Feb 14, 2022
Adapting DNA nanopore sequencing to peptides allows researchers to identify single amino acid differences.
Cracking Down on Cancer: A Profile of Owen Witte
Diana Kwon | Apr 1, 2020
Through his studies on cancer-causing viruses, the University of California, Los Angeles, professor has helped develop lifesaving treatments.
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Using Nanopores to Sense and Sequence Proteins
The Scientist Creative Services Team | Aug 30, 2021
Aleksei Aksimentiev and Stefan Howorka discuss challenges in amino acid sensing with nanopores and approaches to design efficient protein sequencing technology.
Sergiu Pasca Builds Brains to Study Developmental Disease
Emily Makowski | Dec 1, 2019
The Stanford University professor helped develop a technique to grow brain organoids from induced pluripotent stem cells.
Image of the Day: Fractal Formation
Emily Makowski | Nov 4, 2019
A mixture of chemicals induces reactions reminiscent of life on pyrite.
Bats May Have Taken on Viruses To Stay in Flight
Ashley Yeager | Feb 22, 2018
Dampening the immune response to stay up in the air may have helped bats become tolerant to viral infections.
Genes’ Composition Guides More-Optimal Diets
Ruth Williams | Jun 1, 2017
Fruit flies and mice grow better and eat less when the amino acid balance of their food reflects that coded by their exomes.
A Different Way of Doing Things
Kivanç Birsoy and David M. Sabatini | Apr 1, 2016
Cancer cells exhibit altered metabolic processes that may serve as promising targets for new therapies.
Metabolic Reprogramming
Kivanç Birsoy and David M. Sabatini | Mar 31, 2016
How cancer cells fuel their rapid growth
Fingerprints Yield Sex Info
Karen Zusi | Nov 5, 2015
The amino acids left behind in a human fingerprint can be used to determine whether an individual is male or female.
Early Code
Jef Akst | Jun 3, 2015
New research points to key properties of transfer RNA molecules and amino acids that may have supported the origin of life on Earth.
On the Origins of Life
Jef Akst | Mar 17, 2015
A new experimental system demonstrates that precursors of ribonucleotides, amino acids, and lipids may have simultaneously arisen from the same prebiotic chemistry.
Augmenting the Genetic Alphabet
Kate Yandell | May 7, 2014
For the first time, synthetic DNA base pairs are replicated within living bacteria.
Cysteine Aids Mice with Huntington’s
Kerry Grens | Mar 31, 2014
Rodent models of Huntington’s disease show dysfunctional cysteine production, and adding the amino acid to their diets seems to relieve symptoms.  
Pioneer DNA Researcher Dies
Jef Akst | Oct 2, 2012
Leonard Lerman, who helped elucidate the process from gene to protein, passed away last month at age 87.