Date: March 1, 1999Caspase Substrates and Inhibitors, Apoptosis ProductsCast of Characters
Apoptosis is no less a hot topic than it was a year ago when LabConsumer first looked at the available tools for studying this complex phenomenon.1 In that intervening time, roughly 20 papers per day have been published on apoptosis, an issue of Science devoted to apoptosis has been published,2 and countless new pieces have been added to the puzzle. To get an idea of the complexity of apoptosis in higher species, take a look at the cast of characters (Table on page 19), which is doubtless incomplete. The challenge to those studying this process is to understand how the individual members of this cast interact and function to facilitate cell death or protect cells from it. What makes understanding this process so intriguing is the fact that there are multiple pathways to apoptosis,...

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