Data derived from the Science Watch/Hot Papers database and the Web of Science (ISI, Philadelphia) show that Hot Papers are cited 50 to 100 times more often than the average paper of the same type and age.

Diabetes researchers have long known about the connection between obesity and insulin resistance, but they have yet to identify the hormonal machinery responsible for that connection. In this Hot Paper, published 18 months ago, investigators appeared to have uncovered a major part of that machinery when they discovered the resistin hormone in mice.1 More recent findings, however, have cast doubt on resistin's relevance in human diabetes.

Senior author Mitchell Lazar, director of the University of Pennsylvania Diabetes Center, notes two major factors that helped lead his group to discover resistin. First, based on findings related to leptin, the now infamous hormonal fat-regulator, Lazar knew that fat not only serves to store...

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