Model of an inhibitor targeted to g-secretase interacting with presenilin. The background shows an Alzheimer's brain that carried a presenilin mutation, with immunohistochemistry revealing abundant amyloid plaques (red-orange patches). For years researchers have been perplexed by the identity of g-secretase, an enzyme that cuts amyloid precursor protein (APP) into amyloid ß (Aß) fragments that form telltale plaques in the brains of Alzheimer's patients. Now researchers from Merck Rese
 Model of an inhibitor targeted to g-secretase interacting with presenilin. The background shows an Alzheimer's brain that carried a presenilin mutation, with immunohistochemistry revealing abundant amyloid plaques (red-orange patches). |
Presenilin 1 (PS1) has been linked to AD since PS1 was first identified and cloned in 1995.1 PS1 mutations cause a rare form of early-onset familial AD. Bart ...
A long-term study of nearly 800 patients demonstrated a strong safety profile for T cells engineered with viral vectors.
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In this webinar, Nathan Sepulveda will share how to specifically and reproducibly measure residual HEK293 DNA during biotherapeutic product development.
Today’s thermocyclers are more intuitive and flexible, letting scientists focus on their experiments rather than their instruments.
In this webinar, Alex George will discuss how he used high-dimensional single-cell profiling to analyze immune memory to COVID-19 vaccines in human samples.
A new thermocycler technology helps scientists optimize reactions with six different settable temperature zones for better control and linear gradients.
Long-lasting, bright F-actin staining made easy with Biotium's new ActinBrite™ High Affinity Phalloidin Conjugates.
The Aivia 15 release includes deep learning-powered tools for 2D and 3D cell segmentation.
The integrated solution enables parallel high-resolution analysis of hundreds to thousands of individual cells, addressing growing demand for scalable, multiomics approaches in single-cell research.
From confocal, widefield, and live cell imaging to multimode reading, the Agilent BioTek Cytation C10 confocal imaging reader delivers crisp, high-resolution images and the ability to image and analyze 3D samples.
