Injecting starchy solutions directly into the veins of patients who are suffering from sepsis—dangerously low blood pressure often caused by systemic infection—may do more harm than other treatments, according to recently published research. And next week, scientists at the US Food and Drug Administration (FDA) will mull whether or not to discontinue the treatment based on this and other emerging information.
A study published month in the New England Journal of Medicine (NEJM) found that 201 of 398 patients given a particular brand of hydroxyethyl starch died, compared to only 172 of 400 who received a different IV fluid called Ringer's acetate. Copenhagen University Hospital researcher and physician Anders Perner, lead author on the NEJM study, told Nature that he stopped using IV starch treatment for sepsis as soon as the study's findings became clear. “We changed practice the day we saw the results," he said. "Many Scandinavian ICUs have ...
