Pharma Looks to Inflammasome Inhibitors as All-Around Therapies
Pharma Looks to Inflammasome Inhibitors as All-Around Therapies
Many major biopharmaceutical companies are developing or acquiring drugs that target the NLRP3 inflammasome, a large intracellular complex that researchers say can spark inflammation and stoke diseases of lifestyle and aging.
Pharma Looks to Inflammasome Inhibitors as All-Around Therapies
Pharma Looks to Inflammasome Inhibitors as All-Around Therapies

Many major biopharmaceutical companies are developing or acquiring drugs that target the NLRP3 inflammasome, a large intracellular complex that researchers say can spark inflammation and stoke diseases of lifestyle and aging.

Many major biopharmaceutical companies are developing or acquiring drugs that target the NLRP3 inflammasome, a large intracellular complex that researchers say can spark inflammation and stoke diseases of lifestyle and aging.

clinical trials
CAR Macrophages Tackle Challenges in Solid Cancer Treatment
CAR Macrophages Tackle Challenges in Solid Cancer Treatment
Amanda Heidt | Mar 26, 2021
Following on the success of CAR T cells used to treat cancers of the blood, researchers have launched a Phase 1 clinical trial of genetically modified macrophages to target solid tumors.
AstraZeneca’s COVID-19 Shot Completely Prevented Severe Disease
AstraZeneca’s COVID-19 Shot Completely Prevented Severe Disease
Kerry Grens | Mar 22, 2021
The vaccine was 79 percent effective at blocking symptomatic infections, according to data from a Phase 3 trial in the US, Chile, and Peru. A US safety oversight board says the data might be incomplete.
José Baselga, Renowned Oncologist, Dies at 61
José Baselga, Renowned Oncologist, Dies at 61
Asher Jones | Mar 22, 2021
The cancer researcher and executive vice president of AstraZeneca’s oncology research and development is well known for his role in the development of pivotal breast cancer therapies.
Eli Lilly Claims New Drug Can Slow Alzheimer’s-Related Decline
Eli Lilly Claims New Drug Can Slow Alzheimer’s-Related Decline
Lisa Winter | Mar 16, 2021
Patients who received the drug fared better cognitively and functionally than those taking placebo, but still experienced losses in performance.
COVID-19 Vaccine Combos Aim to Boost Immunity
COVID-19 Vaccine Combos Aim to Boost Immunity
Asher Jones | Mar 9, 2021
Mix-and-match shots could simplify vaccine rollout and stimulate more-robust immune responses. Ongoing clinical trials will soon give answers.
NIH Halts Outpatient COVID-19 Convalescent Plasma Trial
NIH Halts Outpatient COVID-19 Convalescent Plasma Trial
Marcus A. Banks | Mar 4, 2021
The decision adds to evidence that the benefits of plasma infusions from COVID-19 survivors may be limited, but advocates say the case isn’t closed.
Q&A: New Trials Tackle COVID-19 Vaccines in Pregnancy
Q&A: New Trials Tackle COVID-19 Vaccines in Pregnancy
Catherine Shaffer | Feb 25, 2021
Geeta Swamy of Duke University School of Medicine speaks with The Scientist about starting what she considers a long-overdue clinical study of COVID-19 vaccines in pregnant women.
Brain Stimulation Tested to Awaken Coma Patients
Brain Stimulation Tested to Awaken Coma Patients
Shawna Williams | Feb 5, 2021
Two out of three people who received noninvasive ultrasound appear to have gained some level of consciousness, according to preliminary trial results.
High Risk of Bias in Early COVID-19 Studies: Meta-Analysis
High Risk of Bias in Early COVID-19 Studies: Meta-Analysis
Max Kozlov | Jan 14, 2021
Few peer-reviewed clinical papers on the pandemic contained original data, and many of those that did had poor experimental design.