illustration of a brain divided into 4 puzzle pieces
Why Autism Therapies Have an Evidence Problem
Some experts argue that better trials are needed before putting interventions into practice.
ABOVE: © ISTOCK.COM, tasha vector
Why Autism Therapies Have an Evidence Problem
Why Autism Therapies Have an Evidence Problem

Some experts argue that better trials are needed before putting interventions into practice.

Some experts argue that better trials are needed before putting interventions into practice.

ABOVE: © ISTOCK.COM, tasha vector

clinical trials

Special Report
lone birch tree growing sideways in a field
Amid the Terror of War, Efforts to Keep Science Alive in Ukraine
Katarina Zimmer | Mar 28, 2022
Ukrainian scientists and universities face extraordinary challenges as the Russian invasion continues.
A stained tissue sample of metastatic pancreatic cancer
Tetanus Immunity Protects Mice Against Pancreatic Cancer
Amanda Heidt | Mar 24, 2022
Because most people are vaccinated against tetanus as children, delivering benign bacteria carrying a tetanus antigen into pancreatic tumors makes them visible to memory cells in the immune system, researchers report.
istock
AI Helps Predict Winners and Losers in Clinical Trials
Roni Dengler, PhD | Aug 3, 2021
Pradipta Ghosh has plans to revolutionize the drug discovery pipeline.
Zebrafish with fluorescent nervous system in green.
Oust the Mouse: A Plan to Reduce Mammal Use in Drug Development
Natalia Mesa | Mar 15, 2022
The Scientist spoke to Mount Desert Island Biological Laboratory’s Jim Strickland about the institute’s new MDI Bioscience initiative to perform more drug testing and development in nonmammalian models.
An orange CRISPR Cas 9 enzyme cutting DNA
CRISPR-Based Treatment Successfully Lowers Toxic Protein Levels
Natalia Mesa | Mar 2, 2022
A first-of-its-kind gene therapy dramatically reduced misfolded protein levels in some clinical trial participants for up to six months and reduced levels in all participants for up to a year.
Undone Proteins Take Out Bladder Cancer
Roni Dengler, PhD | Jul 20, 2021
An unfolded protein found in human milk shows promise in early clinical trials to treat bladder cancer.
Doctor holding stethoscope in front of European Union flag
New EU Protocol Aims to Improve Clinical Trial Transparency
Sophie Fessl | Feb 16, 2022
A new regulation and registry covering investigational medicinal products mandates reporting and supports multinational trials.
Artist's rendition of a yellow CAR T cell near a red cancer cell surrounded by red blood cells.
Ten Years On, CAR T Cell Recipient Is Still Cancer-Free
Jef Akst | Feb 3, 2022
First, the genetically engineered cells became CD8+ killer T cells that wiped out his leukemia. Then they transformed into a stable population of CD4+ helper T cells that continue to circulate in his body.
The Scientist's LabTalk - Episode 4
The Scientist Creative Services Team | Dec 11, 2020
The Past, Present, and Future of Gene Therapy: How to Scale-up Successfully
blue and white building sign
Biden Picks Robert Califf to Head the FDA for a Second Time
Chloe Tenn | Nov 12, 2021
The cardiologist was briefly the FDA Commissioner in the Obama Administration, and now has a second chance to act on plans he tried to implement during his first tenure.
Illustration of neurons in white with myelin in blue
Repurposed Drug Reverses Signs of Alzheimer’s in Mice, Human Cells
Jef Akst | Oct 12, 2021
Researchers say they hope to launch a clinical trial to test bumetanide, a diuretic approved in 2002, but how it might improve neural functioning is unclear.
The MSC: Regeneration Orchestrator
The Scientist Staff | Nov 16, 2020
Scientists uncover the promise of mesenchymal stem cells (MSCs), also known as medicinal signaling cells, to modulate the immune system and regenerate tissue.
Updated
Merck research facility in San Francisco
Antiviral Pill Lowers Risks of COVID-19 Hospitalization, Death
Chloe Tenn | Oct 1, 2021
Merck reports that its antiviral molnupiravir was effective against early stages of COVID-19 in high-risk patients in a Phase 3 clinical trial.
An artistic rendering of blue neurons against a white background
Participant’s Diagnosis Halts Gene Therapy Clinical Trial
Amanda Heidt | Aug 12, 2021
The FDA pauses the research program on a lentivirus-based treatment for a rare neurological condition after a patient developed a bone marrow disorder that could presage leukemia.
A person wearing a purple glove holds out a blue pill
Fecal Microbiota Transplantation Is Poised for a Makeover
Shawna Williams | Jun 1, 2021
With multiple microbiota therapeutics in the pipeline for recurrent Clostridium difficile infection, clinicians foresee a shift in treatment options for the condition.
a drawing of black goggles receiving a beam of light than is then transmitted to an eyeball. from the retina there is a zoom-in of blue and purple cells and purple viruses
Blind Patient Recovers Partial Vision with Optogenetics
Alejandra Manjarrez | May 24, 2021
After receiving an intraocular injection of the gene for a light-sensitive protein, a 58-year-old man diagnosed with the neurodegenerative eye disease retinitis pigmentosa was able to locate objects on a table using engineered goggles.
An illustration of a DNA double helix in gold with texture
Gene Therapy Continues to Benefit Kids with Immunodeficiency
Jef Akst | May 12, 2021
Four dozen children with severe combined immunodeficiency (SCID) who received a corrective gene carried by a virus have working immune systems two to three years later, according to three independent clinical trials.
New Malaria Vaccine Shows Most Efficacy of Any to Date: Small Trial
Catherine Offord | Apr 26, 2021
Immunization had up to 77 percent efficacy in a Phase 2 clinical study of 450 children in Burkina Faso.
Pharma Looks to Inflammasome Inhibitors as All-Around Therapies
Rachael Moeller Gorman | Apr 1, 2021
Many major biopharmaceutical companies are developing or acquiring drugs that target the NLRP3 inflammasome, a large intracellular complex that researchers say can spark inflammation and stoke diseases of lifestyle and aging.