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Image of a white cardboard box with a blue vertical stripe on the left side, the word “Apixaban” in blue lettering at the bottom, and a depiction of apixaban’s molecular structure in black.
Blood Thinner Ineffective for COVID-19 Patients: Study
A clinical trial finds that the anticoagulant apixaban, which has been prescribed to help COVID-19 patients recover, is ineffective and in rare instances dangerous.
Blood Thinner Ineffective for COVID-19 Patients: Study
Blood Thinner Ineffective for COVID-19 Patients: Study

A clinical trial finds that the anticoagulant apixaban, which has been prescribed to help COVID-19 patients recover, is ineffective and in rare instances dangerous.

A clinical trial finds that the anticoagulant apixaban, which has been prescribed to help COVID-19 patients recover, is ineffective and in rare instances dangerous.

clinical trials
a person fumigates a red brick pathway to control mosquitoes in the fight against Dengue virus.
European Medicines Agency Recommends Approving Takeda’s Dengue Vaccine
Katherine Irving | Oct 14, 2022 | 2 min read
In clinical trials, the new inoculation demonstrated greater protection for children and people older than 45 than the existing dengue vaccine.
A person in a white shirt activates a nasal spray
Oxford-AstraZeneca Nasal COVID-19 Vaccine Falters in Clinical Trial
Dan Robitzski | Oct 11, 2022 | 2 min read
Researchers say they’re abandoning the project in its current form—one of several that aims to induce what’s known as mucosal immunity against SARS-CoV-2.
A wrecking ball destroying a malignant cell as a 3D illustration
Armored CAR T Cells Break Through Immune Suppression in Solid Tumors
Jennifer Zieba, PhD | 3 min read
Researchers determined the safety and antitumor ability of genetically engineered CAR T cells that circumvent immune suppression in a prostate cancer phase I clinical trial.
A black and white photo of a woman in a plumed hat in a laboratory classroom with several men
Birth of The Pill, 1956–1960
Andy Carstens | Oct 3, 2022 | 2 min read
Researchers overseeing the clinical trial for the first FDA-approved oral contraceptive claimed the drug gave the Puerto Rican participants power over their family planning. Critics claimed the women were exploited.
Illustration of light blue neurons with white amyloid plaques accumulating on their axons.
New Alzheimer’s Drug Slows Cognitive Decline in Clinical Trial
Dan Robitzski | Sep 28, 2022 | 2 min read
The Biogen-developed treatment, called lecanemab, appears to have a more clear-cut effect on slowing the disease than the company’s previous Alzheimer’s drug, Aduhelm.
istock
AI Helps Predict Winners and Losers in Clinical Trials
Roni Dengler, PhD | 4 min read
Pradipta Ghosh has plans to revolutionize the drug discovery pipeline.
Woman holding a glass of water in one hand and pill in the other
Daily Multivitamin May Slow Cognitive Decline in Seniors
Andy Carstens | Sep 14, 2022 | 2 min read
Researchers caution that it’s too soon to recommend supplements based on the results of a new study.
A 3D rendering of a neuron
Independent FDA Advisory Panel Recommends Approving ALS Drug
Amanda Heidt | Sep 8, 2022 | 4 min read
The group’s 7-2 ruling in favor of the therapeutic represents a shift from previous deliberations, in which data on its effectiveness was deemed insufficient.
Undone Proteins Take Out Bladder Cancer
Roni Dengler, PhD | 3 min read
An unfolded protein found in human milk shows promise in early clinical trials to treat bladder cancer.
A red sign that reads “Clinical Center, Building 10” outside of a brick building
NIH Fails to Enforce Rules for Reporting Clinical Trial Results
Amanda Heidt | Aug 18, 2022 | 3 min read
A review by the US Office of Inspector General found that only about half of the scientists running clinical trials funded by the NIH in 2019 and 2020 appropriately recorded their findings in a federal database, as is legally required.
Photograph of Humsa Venkatesh
Humsa Venkatesh Probes Cancer’s Grip on the Brain
Maddie Bender | Aug 15, 2022 | 3 min read
At Brigham and Women’s Hospital, the cancer biologist is combining research into the tumor microenvironment with the principles of neuroscience to tease apart how cancers grow—and how to stop them.
The Scientist's LabTalk - Episode 4
The Scientist’s Creative Services Team | 1 min read
The Past, Present, and Future of Gene Therapy: How to Scale-up Successfully
Building with sign reading “Novartis”
Two Children Die After Receiving Novartis Gene Therapy
Andy Carstens | Aug 12, 2022 | 1 min read
No deaths had previously been associated with the muscle-wasting treatment Zolgensma.
EXCLUSIVE
Colorful pills and capsules on a calendar background
Clinical Trial Registry Errors Undermine Transparency
Catherine Offord | Aug 2, 2022 | 10 min read
A lack of comprehension among some researchers about how to use ClinicalTrials.gov may be hindering public access to trial information and holding up drug study results, an investigation by The Scientist finds.
The MSC: Regeneration Orchestrator
The Scientist Staff | 7 min read
Scientists uncover the promise of mesenchymal stem cells (MSCs), also known as medicinal signaling cells, to modulate the immune system and regenerate tissue.
A gloved hand holds a tweezer and pulls a section of DNA away from a double helix
First Person Dosed in Novel Gene Editing Clinical Trial
Amanda Heidt | Jul 12, 2022 | 4 min read
The biotech company Verve Therapeutics launched the study with the aim of using base editing to treat a genetic condition that causes high cholesterol and increases a person's risk of developing cardiovascular disease.
Tiny diverse scientists are studying the covid-19 virus under a giant microscope. Vaccine development concept
Opinion: Many Clinical Trials Fail to Navigate the Literature
Jacky Sheng, Jonathan Kimmelman, and Deborah Zarin | Jul 5, 2022 | 4 min read
Too often, studies that aim to develop new treatments for patients fail to adequately cite and build upon research that preceded them.
A small, brown mouse runs on a narrow, miniature treadmill
How Exercise Helps Mice Fight Pancreatic Cancer
Dan Robitzski | Jun 15, 2022 | 5 min read
A study reveals a molecular pathway linking exercise to an amped-up immune response to pancreatic cancer and greater responsiveness to treatment.
A conceptual 3D illustration of motor neurons degrading
Canada Approves Experimental ALS Therapy
Andy Carstens | Jun 14, 2022 | 3 min read
The country’s provisional go-ahead could increase pressure already being exerted on the US Food and Drug Administration to approve the therapy.
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