clinical trials
Resistance to HIV Engineered Via CRISPR
Resistance to HIV Engineered Via CRISPR
Anna Azvolinsky | Aug 3, 2017
Mice transplanted with human hematopoietic stem cells that have an HIV receptor gene, CCR5, disrupted by gene editing allows the animals to ward off HIV infection. 
Opinion: Biobanking Has a Consent Dilemma
Opinion: Biobanking Has a Consent Dilemma
Timothy Caulfield | Jul 25, 2017
Is the deep uncertainty surrounding fundamental legal and ethical norms putting biobanks in a precarious position? 
Personalized Cancer Vaccines Show Promise for Melanoma
Personalized Cancer Vaccines Show Promise for Melanoma
Jef Akst | Jul 6, 2017
In two early trials, vaccines tailored to the mutations in individuals’ cancers appeared to protect 12 of 19 patients against relapse. 
More Than 1 Percent of Clinical Trial Reports Appear Flawed
More Than 1 Percent of Clinical Trial Reports Appear Flawed
Jef Akst | Jun 5, 2017
A new screening tool flags dozens of papers with potential errors.
More than 18,000 Genomic Records from Cancer Patients Available
More than 18,000 Genomic Records from Cancer Patients Available
Kerry Grens | Jun 1, 2017
The publicly available database found nearly a third of samples included mutations targeted by either approved drugs or therapies in clinical trials. 
Opinion: Token Pharmacovigilance
Opinion: Token Pharmacovigilance
Peter Doshi | May 23, 2017
A US government website for collecting reports of side effects associated with vaccines is broken. Why has no one noticed?
First In Vivo Human Genome Editing to Be Tested in New Clinical Trial
First In Vivo Human Genome Editing to Be Tested in New Clinical Trial
Abby Olena | May 18, 2017
Sangamo Therapeutics will use zinc finger nucleases to introduce the gene for a missing clotting factor into the livers of men with hemophilia B.
Stem Cell Trial Data Mostly Go Unpublished
Stem Cell Trial Data Mostly Go Unpublished
Anna Azvolinsky | May 5, 2017
Less than half of completed stem cell studies in humans are published in peer-reviewed journals, according to an analysis of regenerative medicine trials. 
Cell Lines Gain Cancer-Related Mutations
Cell Lines Gain Cancer-Related Mutations
Kerry Grens | Apr 27, 2017
A screen of human embryonic stem cell lines finds several that accumulated changes in the gene TP53, including aberrations commonly seen in cancer.
DNA-Based Zika Vaccine Reaches Phase 2
DNA-Based Zika Vaccine Reaches Phase 2
Tracy Vence | Apr 4, 2017
An NIAID-sponsored clinical trial advances beyond safety testing.