Zebrafish with parts of nervous system in green.
Oust the Mouse: A Plan to Reduce Mammal Use in Drug Development
The Scientist spoke to Mount Desert Island Biological Laboratory’s Jim Strickland about the institute’s new MDI Bioscience initiative to perform more drug testing and development in nonmammalian models.
ABOVE: Marko Pende, Science Advances
Oust the Mouse: A Plan to Reduce Mammal Use in Drug Development
Oust the Mouse: A Plan to Reduce Mammal Use in Drug Development

The Scientist spoke to Mount Desert Island Biological Laboratory’s Jim Strickland about the institute’s new MDI Bioscience initiative to perform more drug testing and development in nonmammalian models.

The Scientist spoke to Mount Desert Island Biological Laboratory’s Jim Strickland about the institute’s new MDI Bioscience initiative to perform more drug testing and development in nonmammalian models.

ABOVE: Marko Pende, Science Advances

pharmaceuticals

a man collects water using a fishing pole and can
World’s Rivers Rife with Drugs: Study
Christie Wilcox | Feb 15, 2022
Levels of pharmaceuticals considered unsafe for aquatic organisms were found at more than one-quarter of sampling sites.
Insight into Dexamethasone’s Benefits in Severe COVID-19
Abby Olena | Jun 19, 2020
The steroid’s exceptional performance in early results from the RECOVERY clinical trial in the United Kingdom is a rational outcome of the drug’s anti-inflammatory effects, experts say.
Discover how flow cytometry accelerates drug screening
Adapting Flow Cytometry for Drug Discovery Workflows
The Scientist Creative Services Team, Bio-Rad Laboratories | May 3, 2022
Explore how flow cytometry innovations expand and accelerate cell profiling.
Judge Rules Unreported Clinical Trial Data Must Be Made Public
Amy Schleunes | Feb 26, 2020
The sponsors of upwards of 1,000 clinical trials may be forced to publish data that have gone unpublished over a 10-year period.
Biogen, Eisai End Two Late-Stage Trials for Alzheimer’s Treatment
Emily Makowski | Sep 16, 2019
The widely expected move comes months after the companies scrapped trials of another Alzheimer’s drug.
Learn about universal documentation for easy compliance testing
Simplify Laboratory Compliance with Universal Documentation
The Scientist Creative Services Team, PerkinElmer | Apr 21, 2022
Universal electronic documentation takes care of instrument compliance testing, allowing researchers to get back to the bench.
How the Brain Changes on Ketamine: A Live Animal Study
Ruth Williams | Apr 11, 2019
The drug promotes and sustains brain cell connectivity in mice, reversing the effects of chronic stress.
removing chemotheraphy drugs
Mopping Up Excess Chemotherapy Drugs
Ruth Williams | Apr 1, 2019
A prototype in-vein device would collect toxic medications before they reach healthy tissues.
Clear and Easy Flowing: Analyzing Antibody Self-Interactions
Strategies for the Rapid Assessment of Antibody Self-Interactions and Improved Formulations Development
The Scientist Creative Services Team, Sartorius | Feb 2, 2022
Martin Domnowski explains how sequence and formulation affect antibody self-interaction properties, and how researchers detect these interactions in low concentration samples.
the Lasker award trophy
Lasker Awards Recognize Work on Histones, Anesthesia, RNA
Shawna Williams | Sep 11, 2018
This year’s winners are C. David Allis, Michael Grunstein, John Glen, and Joan Steitz.
FDA Approves First Marijuana-Derived Drug
Shawna Williams | Jun 25, 2018
As the CBD-based medication enters the market, the agency promises a crackdown on producers of cannabidiol products that make unproven claims.
Learn How to Accurately Determine Protein Conformation
Focus on Structure to Verify Protein Function
The Scientist Creative Services Team, RedShift Bio | Oct 6, 2021
Scientists analyze a therapeutic protein’s secondary structure to confirm drug efficacy and safety.
Researchers Getting Smarter About Pairing Cancer Treatments
Anna Azvolinsky | Apr 1, 2018
Multidrug combinations lead to better results for cancer patients, but efficiently identifying them is proving difficult.
Infographic: Cancer Drug Pairings
Anna Azvolinsky | Mar 31, 2018
Researchers use several different strategies to deliver a one-two punch.
Detecting Subvisible Particles in Protein Therapeutics
The Scientist Creative Services Team in collaboration with Yokogawa Fluid Imaging Technologies | Feb 16, 2021
New flow imaging microscopy technology visualizes a broad range of subvisible particles hidden in therapeutic suspensions.  
Pfizer to Halt Alzheimer’s and Parkinson’s Drug Research
Jim Daley | Jan 7, 2018
The company’s recent effort to find new treatments for Alzheimer’s ended in disappointment.
Clinical Trial Reporting for Pharma-Sponsored Trials Shows Improvement
Diana Kwon | Dec 4, 2017
The Good Pharma Scorecard finds some big pharmaceutical companies are meeting legal standards for disclosing results—but many studies still go unreported.
One Size Does Not Fit All: Pharmacogenomics in Precision Medicine
The Scientist Creative Services Team | Feb 10, 2021
Sandosh Padmanabhan and Andrew Morrow will discuss how pharmacogenomics methods improve precision medicine for cardiovascular disease treatment.
RNA Interference Drug Excels in Clinical Trials to Treat Rare Disorder
Katarina Zimmer | Nov 3, 2017
If approved, patisiran will be the first RNAi therapeutic on the market.