Genes contributing to heart attack identified

Loci on chromosomes two, three and 20 are implicated in susceptibility to myocardial infarction.

| 1 min read

Register for free to listen to this article
Listen with Speechify
0:00
1:00
Share

Currently only about half of heart attack cases can be attributed to known risk factors and it is likely that a limited number of genes may be involved in the development of acute coronary syndromes. In 1 May Arteriosclerosis, Thrombosis, and Vascular Biology, Stephen Harrap and colleagues from the University of Melbourne, have identified areas on chromosomes two, three, and 20 that may render individuals susceptible to myocardial infarction (MI) and unstable angina (Arterioscler Thromb Vasc Biol 2002, 22:874-878).

In the Acute MI Genetic Origins (AMIGO) study, Harrap et al. used genetic maps to scan the chromosomes of 61 pairs of siblings reporting MI before the age of 70 years. These results were then compared with 91 MI control patients who had no history of sibling MI.

Multipoint linkage analysis in 53 sibling pairs indicated that three regions of DNA had a lod score exceeding 1.5. These regions were found ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member? Login Here
Share
A greyscale image of cells dividing.
March 2025, Issue 1

How Do Embryos Know How Fast to Develop

In mammals, intracellular clocks begin to tick within days of fertilization.

View this Issue
Discover the history, mechanics, and potential of PCR.

Become a PCR Pro

Integra Logo
3D rendered cross section of influenza viruses, showing surface proteins on the outside and single stranded RNA inside the virus

Genetic Insights Break Infectious Pathogen Barriers

Thermo Fisher Logo
A photo of sample storage boxes in an ultra-low temperature freezer.

Navigating Cold Storage Solutions

PHCbi logo 
The Immunology of the Brain

The Immunology of the Brain

Products

Sapio Sciences

Sapio Sciences Makes AI-Native Drug Discovery Seamless with NVIDIA BioNeMo

DeNovix Logo

New DeNovix Helium Nano Volume Spectrophotometer

Olink Logo

Olink® Reveal: Accessible NGS-based proteomics for every lab

Olink logo
Zymo Logo

Zymo Research Launches the Quick-16S™ Full-Length Library Prep Kit