Genetic susceptibility to infertility

Unsuccessful attachment and implantation of blastocysts in the endometrium is the main reason for infertility and failure of in vitro fertilization techniques. MUC 1 mucin, an oxygen-glycosylated (O) epithelial glycoprotein, extends beyond the endometrial glycocalyx and is probably the first molecule that the embryo encounters on attachment. In 28 April Lancet Andrew Horne and colleagues from Imperial College School of Medicine, London suggest that women with unexplained infertility might have a genetic susceptibility to failure of embryo implantation due to small MUC 1 mucin allele size.

Horne et al assessed the variation in the size of the MUC 1 gene in 20 women (ten infertile and ten who had had successful pregnancies). The median of the lower allele size in the infertile group was only 2.5 kb compared with 3.4 kb in the fertile group (p=0 0029, difference 0·9, [95% CI 0 1–1 3]) (Lancet 2001, 357:1336-1337).

The authors believe ...